The Gay and Lesbian Community Center of Southern Nevada Photograph Collection contains mainly candid photographs of events and individuals affiliated with the Las Vegas-based Gay and Lesbian Community Center of Southern Nevada (GLCCSN) dating from 1993 to 2000. Photographs depict events honoring prominent members of the gay, lesbian, bisexual, transgender, and queer community; meetings at GLCCSN; and candidate nights for members of the community running for public office.

The collection is comprised of sixty-four black-and-white digital photographs of Holocaust survivors who live in Las Vegas, Nevada. The photographs were taken by Lyn Robinson in 2012 for a photographic exhibit, the Wall of Hope. The permanent exhibit is on display at the Sperling Kronberg Mack Holocaust Resource Center in Las Vegas, Nevada.

The Irving Hirshon Photographs are comprised of 55 color slide photographs taken by Irving Hirshon in 1971 of Lake Mead, Hoover Dam, downtown Las Vegas, and the Las Vegas Strip. Hirshon is believed to have taken the slides in the summer of 1971 on a West Coast trip to celebrate his twenty-fifth wedding anniversary.

The Arthur H. Wolf Photographs of the Women’s March and March for Science collection is comprised of digital photographs taken by Arthur H. Wolf using his iPhone of two protests that took place in Las Vegas, Nevada in 2017. The first set of photographs were taken during the Women’s March in downtown Las Vegas on January 21, 2017. The second set of photographs were taken during the March for Science on April 22, 2017. Accompanying each set of photographs is a document with Wolf’s notes explaining the purpose of the events and describing his experience attending them.

The collection is comprised primarily of photographs of Rabbi Yocheved Mintz at different events and programs held at Las Vegas, Nevada synagogue Congregation P'nai Tikvah from 2006 to 2017. The collection includes photographs of congregants during different workshops and events held at the synagogue. The collection also includes photographs of Rabbi Mintz and congregants during holidays (Hannukah, Purim, Rosh Hashanah, and Passover), Jewlicious (Jewish education classes and workshops), and from the congregation newsletter.

The October 1 Vigil Photographs are comprised of 47 digital photographs taken by photographer Miranda Alam in 2017 of vigils held around Las Vegas, Nevada after the mass shooting that occurred on October 1, 2017 at the Route 91 Harvest music festival. The photographs include vigils held around Las Vegas at locations such as the "Welcome to Fabulous Las Vegas" sign and the Las Vegas Healing Garden.

The Sheree Downs Las Vegas, Nevada Photographs are comprised of photographs Downs took between 1976 and 1995 during visits to Las Vegas, Nevada. The photographs document the evolution of hotel and casino architecture and signage on the Las Vegas Strip and in downtown Las Vegas. Also included are photographs of various tourist attractions in Las Vegas and souvenirs from casinos.

The Southern Nevada Neon Survey Records (2002-2003, 2016-2018) are comprised of digital photographs and survey forms documenting neon signs in Las Vegas, Nevada. The records represent work done for the Neon Survey, which was a collaborative project conducted by the Neon Museum and the University of Nevada, Las Vegas University Libraries Special Collections and Archives. The survey forms document information on each sign such as the name and address associated with the signs, physical condition, artistic significance, and general history.

This collection is comprised of publicity photographs of Howard Hughes and his aircrafts, from approximately the 1940s to the 1950s, that were compiled by David Rea, former pilot for Hughes Aircraft Company. This collection also includes clippings and technical drawings of Hughes aircrafts.

The Greg Cava Photograph Collection (approximately 1980 to 2003) is comprised of work created by Las Vegas, Nevada photographer Greg Cava. It includes photographs, negatives, and slides that document Las Vegas entertainment, sporting events, and hotel-casino development. The collection also includes material from Cava's time as photographer for the University of Nevada, Las Vegas (UNLV) athletic events, including photographs, programs, and media guides from the UNLV basketball and football teams.