The McCall Family Papers are comprised primarily of family photographs and correspondence from 1910-1970. The materials concentrate on Quannah McCall and his daughter, Connie McCall, both were well known dentists in Southern Nevada. The materials also contain letters, postcards, holiday cards, and birth, death, and marriage certificates, as well as school commencement announcements for family members.

The Yucca Mountain Environmental Safety Collection (1970-2011) consists of reports and impact studies collected by Clark County's Nuclear Waste Division library for documenting Yucca Mountain's potential health and safety risks to Southern Nevada. The reports contain documents pertaining to potential environmental, health, financial, and safety risks from the Yucca Mountain Nuclear Waste Repository, which is located in Nye County, Nevada. The collection contains scientific and social studies in support of and opposition to the site. The bulk of the collection includes licensing reports, site selection studies, and impact studies from transporting, storing, and handling radioactive waste and spent nuclear fuel.

The Chester Longwell Photograph Collection consists of 608 black-and-white photographic prints dating from approximately 1910 to 1930. The images primarily depict the Longwell family's excursions in the Southern Nevada region, primarily to Mount Charleston, Nevada. Also included are images of Southern Nevada mines and mining towns, as well as Pubelo Grande de Nevada, the Lost City. The remaining images depict geological formations and features, as well as forestry and nature scenes in Nevada and Arizona.

The Ferron and Bracken Photograph Collection depicts Southern and Central Nevada and other western states from 1890 to 1961. The photographs primarily depict the development and growth of early Las Vegas, Nevada; mines and mining operations in Southern and Central Nevada; towns and mines in Nevada; and the Hoover (Boulder) Dam and the Colorado River.

The Harrah’s Entertainment, Inc. Photograph Collection contains black-and-white and color photographic prints, negatives, postcards, and slides of William "Bill" Harrah at events in Nevada between approximately 1930 and 1991. Also included are views of Harrah’s Nevada properties including Harrah’s Lake Tahoe Hotel and Casino, Harrah’s Reno Hotel and Casino, and the Holiday Inn Hotel and Casino (that later became Harrah’s Las Vegas Hotel and Casino).

The Sister Klaryta Antoszewska Photograph Collection (1977-1991) consists of photographic slides that depict various Nevada, United States, and international nuclear test protests. The collection includes images of Sister Klaryta Antoszewska and Sister Rosemary Lynch, as well as images of the Lenten Desert Experience and numerous protests at the Nevada Test Site. Also included are images of nuclear testing, soldiers, and anti-nuclear testing promotional materials.

The Maria LaCavera Papers (1947-2017) contain the papers of professional dancer Maria LaCavera. The collection documents the career of LaCavera dancing in Las Vegas, Nevada at the Flamingo Hotel in 1947, and the Last Frontier Hotel in 1949 as one of the Ramona Girls dancing in the Danny O'Neil Varieties Act. Materials include photographs of LaCavera and other Ramona Girls, newspaper clippings, correspondence, LaCavera's American Guild of Variety Artists (AGVA) employment contracts, Fabulous Las Vegas magazines, and hotel receipts. Other items of note include photographs of the 1949 Helldorado parade, a Frontier Hotel Ramona Room menu, and Frontier Hotel ephemera. There is also a copy of a self-published biography of LaCavera, written by her daughter-in-law Kristin Meyer entitled From Bon-Air to the Last Frontier. The collection also contains the digital images used to illustrate the book.