The Howard Hughes Professional and Aeronautical Photographs contain black-and-white photographs of businessman and entrepreneur Howard Hughes and his companies from 1916 to 1997. The photographs primarily depict Hughes alongside his aircraft, including the XF-11 prototype reconnaissance plane and the HK-1 Hercules, better known as the "Spruce Goose" or "Flying Boat." The photographs also cover the companies owned by Hughes, including Hughes Tool Company, Hughes Aircraft Company, Hughes Electronics Corporation, and RKO Pictures.

The Ruby Duncan Photograph Collection on Operation Life (1970s-1980s) is comprised primarily of photographic prints with some corresponding 35 mm negatives of Ruby Duncan and other Operation Life organizers, as well as important organization buildings. Materials include photographs of Ruby Duncan, Aldine Weems, Renee Diamond, and Jack Anderson in the original Operation Life Las Vegas, Nevada Operation Life headquarters and the regional office in San Francisco, California. Also pictured are other employees and beneficiaries of the organization at a Christmas Party.

The William N. Thompson Photographic Slide Collection (approximately 1955-2002) consists of color photographic slides of gaming establishments in the United States, Canada, Mexico, Central and South America, Europe, Asia, and Australia. In addition to images depicting the interior and exterior of casinos, the photographs also include maps showing legal gambling in different regions, and images of brothels, racetracks, hotels, in the United States and internationally.

The Donn Arden Photographs (approximately 1920-1989) contain photographs, negatives, and photographic slides of dancer and choreographer Donn Arden. The photographs primarily document Arden's life as a dancer and choreographer in Las Vegas, Nevada and in Paris, France, including performances at the Stardust Hotel, Desert Inn, and MGM Grand in Las Vegas and the Lido in Paris. The photographs also depict rehearsals, dancers, showgirls, Arden's friends and family, and performance locations.

The Frank Mitrani Photographs depict people and events in Las Vegas, Nevada from 1953 to 2010. The photographs are primarily portraits of Las Vegas businesspeople, including realtors, salespeople, insurance agents, bankers, and executives. The photographs depict several service organizations operating in Southern Nevada, including the Rotary Club of Las Vegas, the Las Vegas Jaycees, the Elks Lodge, and the Assistance League. The photographs also depict hotels and casinos, politicians and political campaigns, news organizations, schools, the Elks Lodge, healthcare professionals, weddings and engagements, and religious events.

The Bill Willard Photograph Collection depicts Las Vegas, Nevada, hotels and casinos in Las Vegas, the Las Vegas Valley, and Laughlin, Nevada from 1905 to 1919 and from 1940 to 1999. The photographs primarily depict hotels and casinos in Las Vegas, including the Sahara Hotel, Circus Circus Hotel and Casino, MGM Grand Las Vegas Hotel and Casino, Caesars Palace, Flamingo Hotel, and the Aladdin Hotel. The photographs also depict students at Nevada Southern University (predecessor of the University of Nevada, Las Vegas), the city of Las Vegas, industrial plants in Henderson and Apex, Nevada, and events in Laughlin, Nevada.

The Las Vegas Bugle Photograph Collection on Lesbian, Gay, Bisexual, and Transgender History (1993-2002) consists of photographic prints, negatives, and contact sheets chronicling events and activities of the lesbian, gay, bisexual, and transgender communities throughout southern Nevada. Many of the photographs originally accompanied newspaper articles published in the Las Vegas Bugle.