The Las Vegas, Nevada Gay, Lesbian, Bisexual, Transgender, and Queer/Questioning (LGBTQ) Collection documents the social and political activities of Las Vegas, Nevada's LGBTQ community from 1955 to 2020. The collection includes hundreds of newspaper articles about LGBTQ issues, ranging from AIDS to Nevada legislation. The collection also documents the presence of the LGBTQ community in Las Vegas, including material from gay bars, nightclubs, social clubs, advocacy and political organizations, entertainers, and student groups. Previously known as the Las Vegas Gay, Lesbian, Bisexual, and Transgender Collection.

The Martha C. Knack and Omer C. Stewart Research Papers on the Pyramid Lake Paiute Tribe contains materials collected by Stewart and Knack as research for their 1984 book, As Long as the River Shall Run: An Ethnohistory of Pyramid Lake Indian Reservation. The collection focuses on the Pyramid Lake Paiute Reservation in Northeastern Nevada from 1845 to 1975 and include letters, journal articles, legal documents, government documents, treatises, and records. All materials are photocopies of documents that date between approximately 1845 to 1980.

The Pueblo Grande de Nevada Manuscript Collection (1924-1983) contains journal articles, photocopies of artifact inventories, reports, correspondence, and field notes related to the Pueblo Grande de Nevada archaeological site located in the Overton Valley of Southern Nevada. The bulk of the materials are related to Mark R. Harrington's archaeological reports, journal articles, and data from sites throughout the Overton and Moapa valleys. The collection also includes materials related to the Boulder Dam Park Museum (Lost City Museum of Archaeology) located in Overton, Nevada, which housed many of the artifacts and photographs from Harrington's archaeological sites.

The Bob Stupak Professional Papers (approximately 1900 to 2007) primarily documents the career of Las Vegas, Nevada casino owner, Bob Stupak. The materials in the collection include the planning of two resorts in Las Vegas, Nevada created by Bob Stupak: Vegas World and the Stratosphere. The collection also includes planning materials for the Titanic Las Vegas, an unbuilt resort envisioned by Stupak. Planning and promotional materials for Stupak's resorts including photographs, memorabilia, audiovisual materials, advertising mockups, and architectural drawings. The collection includes several scrapbooks and photographs of Stupak and his wife Sandy at events around Las Vegas. The materials also document Stupak's political campaigns running for mayor of Las Vegas in 1983 and 1987 and lieutenant governor of Nevada in 2006.