The William N. Thompson Photographic Slide Collection (approximately 1955-2002) consists of color photographic slides of gaming establishments in the United States, Canada, Mexico, Central and South America, Europe, Asia, and Australia. In addition to images depicting the interior and exterior of casinos, the photographs also include maps showing legal gambling in different regions, and images of brothels, racetracks, hotels, in the United States and internationally.

The Donn Arden Photographs (approximately 1920-1989) contain photographs, negatives, and photographic slides of dancer and choreographer Donn Arden. The photographs primarily document Arden's life as a dancer and choreographer in Las Vegas, Nevada and in Paris, France, including performances at the Stardust Hotel, Desert Inn, and MGM Grand in Las Vegas and the Lido in Paris. The photographs also depict rehearsals, dancers, showgirls, Arden's friends and family, and performance locations.

The Bill Willard Photograph Collection depicts Las Vegas, Nevada, hotels and casinos in Las Vegas, the Las Vegas Valley, and Laughlin, Nevada from 1905 to 1919 and from 1940 to 1999. The photographs primarily depict hotels and casinos in Las Vegas, including the Sahara Hotel, Circus Circus Hotel and Casino, MGM Grand Las Vegas Hotel and Casino, Caesars Palace, Flamingo Hotel, and the Aladdin Hotel. The photographs also depict students at Nevada Southern University (predecessor of the University of Nevada, Las Vegas), the city of Las Vegas, industrial plants in Henderson and Apex, Nevada, and events in Laughlin, Nevada.

The Marie and James B. McMillan Photograph Collection (1900-1994) contains photographs of Marie and James B. McMillan and their families. The collection also includes photographs of their friends and professional associates, including journalist Hank Greenspun, Nevada civil rights pioneer J. David Hoggard, and entertainer Sammy Davis Jr. Marie McMillan is a former Las Vegas, Nevada flight instructor and one of the first women to work at the Nevada Test Site in Nye County, Nevada. James B. McMillan was the first African-American dentist to practice in Nevada, as well as a prominent Nevada civil rights leader.

The Ferron and Bracken Photograph Collection depicts Southern and Central Nevada and other western states from 1890 to 1961. The photographs primarily depict the development and growth of early Las Vegas, Nevada; mines and mining operations in Southern and Central Nevada; towns and mines in Nevada; and the Hoover (Boulder) Dam and the Colorado River.

The Squires Family Photographs document the Squires Family and the development of the Las Vegas Valley in Nevada from approximately 1860 to 1980, with a bulk of the photographs depicting people and events from 1900 to 1950. The photographs depict the Euro-American settlement and growth of Las Vegas, Nevada; traveling and exploration of Southern Nevada and the Southwestern United States; the Hoover (Boulder) Dam and the Colorado River; clubs and social groups; and the Squires Family, especially prominent newspaper editor and publisher Charles Pember (C. P. or “Pop”) Squires, Delphine “Mom” Anderson Squires, and their children.

The Harry Floyd Alter Photograph Collection (1905-1916) is comprised of black-and-white photographic prints and negatives. The images depict scenes in Las Vegas, Nevada, including the Las Vegas Ranch, the Arizona Club, and baseball teams and fields. Also included are images of Harry Floyd Alter and his friends.