The Bill Hughes Photographs (approximately 1980-2012) contains negatives, slides, prints, proofs, and born digital images created by local photographer and photojournalist Bill Hughes for publications including Las Vegas CityLife, Las Vegas Business Press, Las Vegas Weekly, as well as commercial clients. A portion of prints in the collection consist of modeling photographs Hughes took as part of his business. The digital images represent a variety of clients, and feature local bands, DJs, and performers in nightclubs and bars on the Strip and downtown Las Vegas. Also included in digital files are portraits, artistic photographs and self-portraits, and material used for Las Vegas Weekly, CityLife, and Business Press.

The Howard Hughes Public Relations Photograph Collection depicts the activities of businessman Howard Hughes from 1930 to 1950. The photographs primarily depict aircraft flown by Hughes or designed by the Hughes Aircraft Company, including the XF-11 reconnaissance plane, the HK-1 Hercules (or "Spruce Goose"), and the Hughes H-1 Racer. The photographs also depict celebrations following Hughes's circumnavigation flight in New York City, New York and Chicago, Illinois in 1938. Lastly, the photographs include Hughes testifying in front of the Senate Special Committee to Investigate the National Defense Program in 1947.