The Howard Hughes Professional and Aeronautical Photographs contain black-and-white photographs of businessman and entrepreneur Howard Hughes and his companies from 1916 to 1997. The photographs primarily depict Hughes alongside his aircraft, including the XF-11 prototype reconnaissance plane and the HK-1 Hercules, better known as the "Spruce Goose" or "Flying Boat." The photographs also cover the companies owned by Hughes, including Hughes Tool Company, Hughes Aircraft Company, Hughes Electronics Corporation, and RKO Pictures.

The Howard R. Hughes College of Engineering Records contain materials dating from approximately 1968 to 2017 that document the establishment of the School of Engineering and later the Howard R. Hughes College of Engineering School. Materials include records of the Nevada Development Authority Partners for Industry through Engineering and Education (PiE2) program during the 1980s that was headed by Bob Gore of Summa Corporation (formerly known as the Howard Hughes Corporation). Collection records also include samples of class listings, phone directories, degree information, college rules and bylaws, and fact sheets and brochures for different engineering degree programs at UNLV. Materials also include accreditation questionnaires from 1989, 1990, and 1992. Also included are promotional brochures and pamphlets for the school from 2015 to 2017.

The Howard Hughes Film Production Records (1912-1992) represent Howard R. Hughes, Jr.'s Hollywood film production achievements through records from companies owned or established by Hughes. The bulk of the records date between 1926 and 1960 and include production and corporate materials from sixteen films, as well as materials related to Hughes' organizations outside of film development. Materials include documents, photographic prints and negatives, blueprints, line drawings, newspaper clippings, posters, paintings, and artifacts.