The subject files series (1999-2012) contain documents and digital files pertaining to Congresswoman Shelley Berkley's activities as U.S. Representative. Topics include healthcare, veterans, the environment, LGBTQ rights, and trade issues. Also included in the series are speeches, talking points, and interviews.

The Yucca Mountain files series (1987-2008) documents Nevada Congresswoman Shelley Berkley's efforts to preventing nuclear waste from being stored in Nevada. Material includes correspondence and court documents involving the Department of Energy (DOE), impact reports, congressional hearings, transportation issues, and constituent concerns.

The correspondence and newspaper clippings series (1999-2012) contains letters directed to and from the United States Congress and Congresswoman Shelley Berkley, as well as newspaper clippings. The most prevalent subjects of the correspondence are agriculture, education, foreign affairs, health care, veterans and women's issues. Also included in the series is a group of campaign related mass mailers.

The digital files subseries (1999-2012) primarily consists of documentation related to issues important to Shelley Berkley's constituents, including the economy, environment, security, education, housing, international relations, and the rights of under-represented communities. Files include supporting documents and talking points used for Congressional speeches, committee work, events, and interviews. Berkley's speeches are captured in textual documents as well as some video recordings of speeches she gave on the floor of Congress and in committees. Files also include correspondence to fellow members of Congress, other government officials, and constituents related to the issues documented in the series.