The Kathy Eastland Papers (1972-2003) document Kathy Eastland's experiences working in Nevada brothels. Materials include ephemera and memorabilia collected by Eastland from various brothels in Nevada such as the Mustang Ranch, the Moonlite BunnyRanch, and Old Bridge Ranch. Included in the collection are brothel menus and photographs of Eastland and other sex workers socializing in the brothels. The collection also contains notes, research, and drafts of Eastland's manuscript Hell on Heels which describe her experience working in the brothel industry. Also included are prototypes of a game created by Eastland called "Brothelopoly" and some campaign materials about Jessi Winchester, a former brothel worker who ran for public office in Nevada. There is a small amount of materials about Joe Conforte, former owner of the Mustang Ranch, and some personal effects of Eastland including a motorcycle jacket and storage trunk.

The Alice Key Papers (1936-2004) consist of documents detailing Alice Key’s life and work in the African American community, historic preservation, and labor relations in Las Vegas, Nevada. Included in the collection are awards and certificates documenting Key’s achievements, invitations and programs to events, political and civic correspondence, and magazine and newspaper articles both about Key and written by her. The collection also contains photographs.

The Colorado River Commission of Nevada Reference Library Collection (1922-2000) documents the history of the Colorado River Commission (CRC) and is predominately comprised of books, briefs, memoranda, motions, exhibits, and other documents pertaining to the Arizona v. California litigation occurring between 1931 and 2000. The collection also contains meeting minutes, correspondence, budgets, reports, and other work files relating to the CRC. The CRC, located in Las Vegas, Nevada, is responsible for managing and protecting Nevada’s Colorado River water and power resources.

The Byrd Wall Sawyer Collection primarily consists of Byrd's research files on Nevada from 1930 to 1970. The materials concentrate on her monograph, "Nevada Nomads," as well as her co-authored textbook, "Here is Nevada." The collection also includes speeches, journal articles, memos, research note cards and papers, correspondence, informational booklets and pamphlets, maps, photographs, audiovisual materials, and newspaper articles and clippings.

The Pueblo Grande de Nevada Manuscript Collection (1924-1983) contains journal articles, photocopies of artifact inventories, reports, correspondence, and field notes related to the Pueblo Grande de Nevada archaeological site located in the Overton Valley of Southern Nevada. The bulk of the materials are related to Mark R. Harrington's archaeological reports, journal articles, and data from sites throughout the Overton and Moapa valleys. The collection also includes materials related to the Boulder Dam Park Museum (Lost City Museum of Archaeology) located in Overton, Nevada, which housed many of the artifacts and photographs from Harrington's archaeological sites.