The Las Vegas Archive Memorabilia and Promotional Materials (approximately 1960-2019) contains reproductions of photographs taken of historic landmarks around Las Vegas, Nevada and entertainers like Elvis Presley, Nat King Cole, Frank Sinatra, Dean Martin, and Liberace performing in Las Vegas. The collection also contains digital photographs from 2008 of an airship displaying an advertisement for the M Resort Spa and Casino. There is also memorabilia from the MGM Grand Hotel including a gaming guide, decks of playing cards, and a commemorative drinking glass. The collection also includes several historic postcards depicting Las Vegas, political campaign buttons for local Nevada elections, and greeting cards from U.S. Representative Jim Santini.

The John Wittwer Collection on Agriculture in Nevada (1898-1972) contains the professional papers and records of John Wittwer in his capacity as an Agricultural Extension agent for the University of Nevada from 1921 to 1954. The records are primarily annual reports containing text, photographs, newspaper clippings, and charts that provide a rich chronicle of the conditions of agriculture and ranching in southern Nevada from 1898 to 1972, with the bulk of the material dating from 1929 to 1955. These conditions span water issues, such as flood control and irrigation, to the general difficulties of sustaining agriculture and viable food production in a desert environment. The reports come from the Agricultural Experiment Stations in Clark and Lincoln counties and most contain both a statistical report and a narrative summary.

The Harmon Family Papers consist of the political and personal correspondence of Las Vegas, Nevada pioneer Harley A. Harmon from 1910 to 1934, and his son, Harley E. Harmon, from 1950 to 1966. The collection also includes correspondence, personal papers, and photographs of Harley L. Harmon from approximately 1950 to 1999. Also included are family scrapbooks with wedding announcements, photographs, birthday cards, newspaper clippings, and other ephemera.

The Marie and James B. McMillan Papers (1928-2010) primarily contain documents pertaining to the families and careers of Marie and James B. McMillan. Included in the collection are photographs, biographical materials, newspaper clippings, award certificates, programs, obituaries, scrapbooks, trophies, legal and military documents, and political campaign documents. Marie McMillan is a former Las Vegas, Nevada flight instructor and one of the first women to work at the Nevada Test Site in Nye County, Nevada. James B. McMillan was the first African-American dentist to practice in Nevada, as well as a prominent Nevada civil rights leader.

The Reverend Donald M. Clark Photograph Collection (approximately 1965-1978) is comprised of black-and-white photographic prints and negatives. The bulk of the images portray Reverend Clark’s work with black communities in Las Vegas, Nevada and the Lake Tahoe area. Additional images depict Reverend Clark with various prominent individuals in the civil rights movement, including boxer Joe Frazier and American gospel singer Mahalia Jackson.

The UNLV Athletics Programs and Memorabilia Collection (1974-2002) is comprised of University of Nevada, Las Vegas (UNLV) athletics publications, team yearbooks, and game day programs for UNLV football and men's basketball teams. The majority of the collection documents the UNLV Runnin' Rebels basketball team during the 1980s and 1990s. Other materials include Big West Conference programs and UNLV athletics memorabilia such as a pom-pom, football foundation member stadium seat cushion, plastic megaphone, and mug.

The Neon in Nevada Photograph Collection contains black-and-white and color photographic slides of neon signs from cities and towns in Nevada dating from 1913 to 1989. The collection includes slides from Las Vegas, Reno, Boulder City, Laughlin, Henderson, Lovelock, Winnemucca, Elko, Wells, McGill, Ely, Eureka, Austin, Hawthorne, and Carson City. The collection also includes slides from the Young Electric Sign Company (YESCO) that depict the "sign graveyard" in Las Vegas, Nevada of broken and retired neon signs.