The Thomas J. Osborne Photograph Collection (approximately 1890-1930) consists of black-and-white photographic prints, negatives, and slides. Images depict the family of Thomas J. Osborne, his law office, the family home, and views of the town of Pioche, Nevada and surrounding areas. Several images depict local mines and unidentified mine workers.

The Liberace Fan Memorabilia Collection (1944-2004) consists of fliers, brochures, newspaper articles, show programs, and collectibles chronicling the life and career of famed Las Vegas, Nevada entertainer Liberace. Materials from the Liberace Foundation, various fan clubs, and the Liberace Museum in Las Vegas comprise the bulk of the collection.

The Nan Doughty Family Collection dates from 1845 to 1993 and documents Doughty's personal and professional life. She collected correspondence and papers related to her extended family members including Sallie Bradford, Seymour Kimball Bradford, William Hillman Shockley, and May Bradford Shockley. The collection also includes papers from her father, Thorwald A. Siegfriedt, and her mother, Lou-vee Bradford Siegfried. Doughty used her family histories to write historical essays about early Nevada. The collection includes her professional papers as well as drafts and correspondence related to her writings.

The Minnie Perchetti Photograph Collection (approximately 1902-1959) consists of black-and-white photographic prints and negatives of Tonopah, Nevada and documents Tonopah in the first half of the 20th century. The photographs depict mines, events, buildings, people, and landscapes in Tonopah, Nevada. Included in the collection are photographs of the 1923 fire in Goldfield, Nevada.

Victor Kunkel Collection of Artifacts (1964-1971) consists of the following items: dice sets from Las Vegas hotels; Clark County deputy badges; and a coin and currency collection from all over the world.

The Siegfried and Roy Memorabilia Collection (1990-2000) consists of books, magazines, programs, and visual recordings from the shows of Las Vegas, Nevada entertainers Siegfried and Roy. Several of the books and magazines in the collection have been autographed by Siegfried and Roy.

The Coates Playing Cards Collection (1920s-1960s) consists of sixty-six decks of playing cards collected by Mrs. Phillip A. Coates. The collection includes promotional decks from various businesses, including the Southern Pacific Lines railroad and the Grace Line steamship company. The majority of the decks are of a narrower design to be used in playing canasta or bridge, with many being multi-deck sets.