The Neon in Nevada Photograph Collection contains black-and-white and color photographic slides of neon signs from cities and towns in Nevada dating from 1913 to 1989. The collection includes slides from Las Vegas, Reno, Boulder City, Laughlin, Henderson, Lovelock, Winnemucca, Elko, Wells, McGill, Ely, Eureka, Austin, Hawthorne, and Carson City. The collection also includes slides from the Young Electric Sign Company (YESCO) that depict the "sign graveyard" in Las Vegas, Nevada of broken and retired neon signs.

The Alan Bible Speeches Collection contains speeches made by Alan Bible while he was serving as a United States Senator representing Nevada from 1967 to 1974. The collection documents Bible's work around the state of Nevada, including dedication and commencement speeches, policy speeches, and promotion of the Democratic Party, as well as some speeches delivered in Washington, D.C.

The Production Company Audiovisual Collection consists of commercials, advertising, and political campaigns from approximately 1965 to 1995 created by The Production Company, a television production company founded by Thomas “Bob” Patrick in Las Vegas, Nevada. The collection consists of primarily 16 mm film and video formats such as VHS, U-Matic, Betacam, open reel, Type C, and quadruplex. The videotapes and films in this collection represent advertising and marketing for hotels and casinos, entertainment companies, politicians, and local businesses located in Las Vegas, Nevada.

The Bruce Carlson Photograph Collection (approximately 2000-2009) consists of digital reproductions of Francis and Neeley family photographs taken during the early 1900s throughout Southern Nevada. Notable locations include Pioche, Eagle Valley, and Spring Valley, Nevada. This collection consists entirely of digital surrogates.

The Union Pacific Railroad Collection (1828-1986) is comprised of the original corporate records of the Union Pacific Railroad's operations in Southern Nevada, Utah, and Southern California, particularly focusing on Las Vegas and Los Angeles. The collection documents the purchase of Stewart ranch and the construction of the original depot and town which became modern Las Vegas. The collection also contains the records of the Las Vegas Land & Water Company (LVL&W), a subsidiary of the railroad formed in 1905 to handle the railroad's land transactions. The collection contains office files, correspondence, reports, leases, various legal, governmental and financial document, the collection contains large and small format maps, architectural and engineering drawings, published technical reports, railroad operational manuals, bound legal briefs, ledgers, and payroll and receipt books. The collection also includes the personal files of Walter Bracken, the Union Pacific's special representative in Nevada and vice president of the Las Vegas Land and Water Company, and a paper index of the collection materials.

The John Nichols Photograph Collection (approximately 1930-1950) is comprised of black-and-white photographic prints depicting the western region of the United States including Southern Nevada, the Hoover Dam (then known as Boulder Dam), Lake Mead, and various desert landscapes. Photographs were collected by former Las Vegas and Boulder City, Nevada resident, John Nichols, who is a longtime art collector and gallery owner based in California. The collection includes some photographs taken by American photographer Glenn Davis who was known for photographing the Las Vegas Valley and the construction of the Hoover Dam.

The Archie C. Grant Photograph Collection (1914-1968) contains black-and-white photographs of Nevada politician Archie C. Grant. The materials include photographs of Grant with the Las Vegas Housing Authority at groundbreaking ceremonies, the University of Nevada Board of Regents, and with other Nevada politicians. Materials also contain early photographs of the University of Nevada, Las Vegas campus, including the dedication of Maude Frazier Hall.