The Thomas J. Osborne Photograph Collection (approximately 1890-1930) consists of black-and-white photographic prints, negatives, and slides. Images depict the family of Thomas J. Osborne, his law office, the family home, and views of the town of Pioche, Nevada and surrounding areas. Several images depict local mines and unidentified mine workers.

The Liberace Fan Memorabilia Collection (1944-2004) consists of fliers, brochures, newspaper articles, show programs, and collectibles chronicling the life and career of famed Las Vegas, Nevada entertainer Liberace. Materials from the Liberace Foundation, various fan clubs, and the Liberace Museum in Las Vegas comprise the bulk of the collection.

The Nan Doughty Family Collection dates from 1845 to 1993 and documents Doughty's personal and professional life. She collected correspondence and papers related to her extended family members including Sallie Bradford, Seymour Kimball Bradford, William Hillman Shockley, and May Bradford Shockley. The collection also includes papers from her father, Thorwald A. Siegfriedt, and her mother, Lou-vee Bradford Siegfried. Doughty used her family histories to write historical essays about early Nevada. The collection includes her professional papers as well as drafts and correspondence related to her writings.

The Minnie Perchetti Photograph Collection (approximately 1902-1959) consists of black-and-white photographic prints and negatives of Tonopah, Nevada and documents Tonopah in the first half of the 20th century. The photographs depict mines, events, buildings, people, and landscapes in Tonopah, Nevada. Included in the collection are photographs of the 1923 fire in Goldfield, Nevada.

Victor Kunkel Collection of Artifacts (1964-1971) consists of the following items: dice sets from Las Vegas hotels; Clark County deputy badges; and a coin and currency collection from all over the world.

The Tomiyasu Family Photograph Collection (approximately 1908 to 1991) consists of black-and-white photographic prints of the Tomiyasu family and their farming business in southern Nevada.

The Howard Schwartz Collection on Gaming documents the gaming industry in the United States from 1966 to 2010. The collection includes manuscripts, periodicals, newspaper articles, ephemera, profit and probability profiles and a report from the National Gambling Impact Study Commission.