The Ed W. Clark Photograph Collection contains photographs that depict politicians and businesspeople in Southern Nevada from 1900 to 1975. The photographs depict several Democratic Party members, including U.S. Senators Pat McCarran and Berkeley Bunker, Nevada Assemblyman Harry Edward "Hap" Hazard, and Nevada Governor Edward P. Carville. The photographs also depict political events, including the planting of a tree in the courthouse park of Las Vegas, Nevada, and a parade on Fremont Street in Las Vegas.

The Irving Hirshon Photographs are comprised of 55 color slide photographs taken by Irving Hirshon in 1971 of Lake Mead, Hoover Dam, downtown Las Vegas, and the Las Vegas Strip. Hirshon is believed to have taken the slides in the summer of 1971 on a West Coast trip to celebrate his twenty-fifth wedding anniversary.

The Minnie Perchetti Photograph Collection (approximately 1902-1959) consists of black-and-white photographic prints and negatives of Tonopah, Nevada and documents Tonopah in the first half of the 20th century. The photographs depict mines, events, buildings, people, and landscapes in Tonopah, Nevada. Included in the collection are photographs of the 1923 fire in Goldfield, Nevada.

The Mildred J. Heyer Photograph Collection consists of four black-and-white photographic prints and negatives from approximately 1905 to 1940. The photographs depict early Las Vegas, Nevada street scenes, an irrigation pump, and Liberty’s Last Stand, a prominent saloon in Nevada during Prohibition.

The Harold Minsky Photograph Collection (1957-1977) contains photographic prints, negatives, and slides collected by Las Vegas burlesque show developer Harold Minsky. Subjects include performers in costume, showgirls, comedians, advertisements for shows, performances, and some of the venues at which Minsky's shows were held, including the Thunderbird Hotel and Casino, the Aladdin Hotel and Casino, and the Dunes Hotel in Las Vegas, Nevada.

The Breck Wall Photograph Collection, approximately 1960 to 1980, consists of black-and-white photographic prints depicting comedian and entertainer, Breck Wall, and other cast members of the comedy revue, “Bottom’s Up!” in Las Vegas, Nevada. Images include scenes from sketches performed on the show, group shots of the cast members off-set, and portraits of Wall.

The Leslie Sitton Photograph Collection contains four black-and-white negatives and photographic print reproductions of a Helldorado Parade taking place in Las Vegas, Nevada. Two of the photographs include a stagecoach from the Hotel Last Frontier.