The Southern and Central Nevada photographs depict locations in Southern and Central Nevada from 1890 to 1950. The photographs depict mining operations, mills, animal freight teams, the Colorado River, Euro-American settlers, Valley of Fire, and Native Americans. The photographs also depict the towns of Boulder City, Goodsprings, St. Thomas, Callville, and Moapa. The items described include black-and-white photographic prints, postcards, and negatives; items listed are photographic prints unless otherwise specified. Numbered items inside oversized boxes are photographs within scrapbooks and have been digitized.

Materials contain photographs of the Fallini Family near Twin Springs, Nevada from 1912 to 1965. Materials include photographs of schoolchildren, residents of Tonopah, buildings on the Fallini Ranch, animals, Merger Mill, Eden Creek, and events in Tonopah.