The Howard Hughes Professional and Aeronautical Photographs contain black-and-white photographs of businessman and entrepreneur Howard Hughes and his companies from 1916 to 1997. The photographs primarily depict Hughes alongside his aircraft, including the XF-11 prototype reconnaissance plane and the HK-1 Hercules, better known as the "Spruce Goose" or "Flying Boat." The photographs also cover the companies owned by Hughes, including Hughes Tool Company, Hughes Aircraft Company, Hughes Electronics Corporation, and RKO Pictures.

The Howard Hughes Film Production Records (1912-1992) represent Howard R. Hughes, Jr.'s Hollywood film production achievements through records from companies owned or established by Hughes. The bulk of the records date between 1926 and 1960 and include production and corporate materials from sixteen films, as well as materials related to Hughes' organizations outside of film development. Materials include documents, photographic prints and negatives, blueprints, line drawings, newspaper clippings, posters, paintings, and artifacts.