The Howard R. Hughes College of Engineering Records contain materials dating from approximately 1968 to 2017 that document the establishment of the School of Engineering and later the Howard R. Hughes College of Engineering School. Materials include records of the Nevada Development Authority Partners for Industry through Engineering and Education (PiE2) program during the 1980s that was headed by Bob Gore of Summa Corporation (formerly known as the Howard Hughes Corporation). Collection records also include samples of class listings, phone directories, degree information, college rules and bylaws, and fact sheets and brochures for different engineering degree programs at UNLV. Materials also include accreditation questionnaires from 1989, 1990, and 1992. Also included are promotional brochures and pamphlets for the school from 2015 to 2017.

The Elmer R. Rusco Collection on Ethnicity and Race in Nevada (1964-1972) contains correspondence, court cases, employment information, and research materials compiled by Rusco for a book he was writing on race relations in Nevada.

The Rodney Sumpter Papers on Doe v. Bryan contain the legal files of the lawyer Rodney Sumpter, who represented the appellants in the Nevada District Court case Doe v. Bryan (1985) and subsequent appeal in the Nevada State Supreme Court in 1986. Doe v. Bryan challenged one of Nevada's sodomy laws (NRS 201.190), and the collection contains affidavits, motion requests, correspondence, newspaper clippings, and memoranda regarding the case.

The collection, 1949 to 2006, was compiled by Clifford Olsen, a containment physicist at the Nevada Test Site (NTS). It consists of research notes and working papers written by Olsen and other scientists, publications, epoxy aggregate samples, work-related correspondence, nuclear-test-event data, and interviews conducted by Olsen with work colleagues involved with the NTS.

The Desert Fishes Council Records (1969-1988) consist of resolutions, meeting minutes, symposium programs, agendas, and press releases of the Desert Fishes Council (DFC). The organization is devoted to the study and preservation of Southwestern desert fishes, notably the desert pupfish. The DFC records reflect efforts to bring the plight of desert fishes to the attention of academics and the public as well as highlight the worth of desert lands within the American environmental movement.

The Bob McCaffery Collection on the Save the Hughes Flying Boat Campaign (1980-1983) documents efforts by activists to preserve the plane from destruction and its subsequent acquisition by the Aero Club of Southern California in 1980. The collection contains photographs and newspaper clippings about the Hughes H-4 Hercules flying boat nicknamed the "Spruce Goose" from the 1980s.

This collection is comprised of personal papers and photographs of Reverend Maureen E. Mackey, M.D., physiatrist and co-founder of Rainbow Praise Church in Las Vegas, Nevada. The collection contents span the dates of 1922 to 2014 and details Dr. Mackey's life, including her educational accomplishments, personal life, and religious life. This collection also contains personal papers and photographs of Dr. Mackey's twin brother, Thomas Mackey, III, who passed away from AIDS in 1992. This collection also contains various photographs of Dr. Mackey's parents and family.