Lucille Bruner founded the Las Vegas Art League in 1950 after she moved to the city from Santa Fe, New Mexico. When the City of Las Vegas bought the Twin Lakes Lodge in what is now Lorenzi Park in Las Vegas, Nevada the Las Vegas Art League requested and obtained three buildings in which to teach and display art. The Art League became the Las Vegas Art Museum (LVAM) n 1974.

The Las Vegas Art Museum relocated to the Sahara West Library and Fine Art Museum in Las Vegas, Nevada in 1997. They remained in operation until 2009.

Las Vegas Jewish Film Festival was founded around 2001 by Joshua Abbey. It shows international films, including dramas, comedies, documentaries, and experimental films. The 14th LVJFF was held January 10 to 25, 2015 and was produced by Desert Space Foundation and the Adelson Educational Campus. Major support was provided by the Adelson Family Foundation, the Jewish Federation of Las Vegas, and the Israeli American Council.

The Marjorie Barrick Museum of Natural History was founded as the Museum of Natural History by Richard H. Brooks in 1967 in Las Vegas, Nevada. Brooks was then the director of the Desert Research Institute (DRI). The museum was owned by DRI until the ownership was transferred to the University of Nevada, Las Vegas in 1969. The museum's primary operations included exhibitions that displayed artifacts and artworks of the archaeology, history, and geology of Southern Nevada.