The J. T. McWilliams Photograph Collection contains photographs and postcards from Nevada and Southern California from approximately 1900 to 1970. The materials include postcards depicting Las Vegas, Nevada casinos such as El Rancho Vegas and the Golden Nugget Gambling Hall. The materials also include postcards depicting towns and scenes in Nevada such as Carson City, Rhyolite, Red Rock Canyon, and covered wagons traveling to Las Vegas. Lastly, the materials contain several photographs of the McWilliams family, possibly while they were living in what is now Las Vegas, Nevada.

The Merle and Beulah Frehner Photograph Collection contains photographs of Southern Nevada from 1905 to 1955. The materials include photographs of the Frehner freight teams transporting ore, schools and students in the Moapa Valley, the Colorado River, and parades in Southern Nevada.

The Nellis Air Force Base Photograph Collection contains photographs of Nellis Air Force Base and its predecessor, the Las Vegas Army Airfield, as well as photographs of Rockwell Field and McCarran Airport in Las Vegas, Nevada from 1926 to 1980. The materials contain photographs of military aircraft, hangars, buildings on the base, and aerial photographs of Las Vegas and the surrounding area. The materials also include photographs of the entrance of McCarran Airport, U.S. Senator Pat McCarran, and a mail plane arriving at Rockwell Fields in 1926.

The David Coons Photograph Collection contains photographs and postcards depicting railroads in Nevada, California, and Utah from 1907 to 1956. The photographs depict trains and locomotives from the Tonopah & Tidewater Railroad, Union Pacific Railroad, San Pedro, Los Angeles & Salt Lake City Railroad, Bullfrog-Goldfield Railroad, Las Vegas & Tonopah Railroad, and Tonopah & Goldfield Railroad. The photographs also portray Arden, Nevada and the Arden Plaster Company Plant, Las Vegas High School after a fire, and early Fremont Street in Las Vegas, Nevada.

The H. E. “Hap” Hazard Photographs (approximately 1940-1969) depict politicians in Southern Nevada. Senator Alan Bible, Governor Edward P. Carville, Senator Mike Mansfield and Senator Pat McCarran appear in photographs at political events. Along with images depicting politicians, an aerial shot of downtown Las Vegas, Nevada in the 1950s is also present.

The Fred and Eva Gillhouse Photograph Collection contains photographs and postcards from Nevada and California from 1855 to 1968. The photographs primarily depict buildings in Carson City and Virginia City, Nevada, and Sacramento, California. The photographs also depict Eva Olenna Blood Ruff Gillhouse at her typewriter and with Frank "Pistol Pete" Eaton, the subject of her biography Pistol Pete, Veteran of the Old West.

The Ed W. Clark Photograph Collection contains photographs that depict politicians and businesspeople in Southern Nevada from 1900 to 1975. The photographs depict several Democratic Party members, including U.S. Senators Pat McCarran and Berkeley Bunker, Nevada Assemblyman Harry Edward "Hap" Hazard, and Nevada Governor Edward P. Carville. The photographs also depict political events, including the planting of a tree in the courthouse park of Las Vegas, Nevada, and a parade on Fremont Street in Las Vegas.