The Howard Hughes Professional and Aeronautical Photographs contain black-and-white photographs of businessman and entrepreneur Howard Hughes and his companies from 1916 to 1997. The photographs primarily depict Hughes alongside his aircraft, including the XF-11 prototype reconnaissance plane and the HK-1 Hercules, better known as the "Spruce Goose" or "Flying Boat." The photographs also cover the companies owned by Hughes, including Hughes Tool Company, Hughes Aircraft Company, Hughes Electronics Corporation, and RKO Pictures.

The Ruby Duncan Photograph Collection on Operation Life (1970s-1980s) is comprised primarily of photographic prints with some corresponding 35 mm negatives of Ruby Duncan and other Operation Life organizers, as well as important organization buildings. Materials include photographs of Ruby Duncan, Aldine Weems, Renee Diamond, and Jack Anderson in the original Operation Life Las Vegas, Nevada Operation Life headquarters and the regional office in San Francisco, California. Also pictured are other employees and beneficiaries of the organization at a Christmas Party.

The Bob Parker Photograph Collection consists of twenty-seven black-and-white photographic prints showcasing the construction of the Hoover Dam (Boulder Dam) from approximately 1930 to 1942.