The Milt Palmer Photographs (approximately 1950-1991) contain original and reproductions of photographic prints taken by Milt Palmer, a photographer who worked for the Las Vegas Chamber of Commerce, and later under the division known as the Las Vegas News Bureau. Palmer captured celebrities and entertainers performing their Las Vegas shows, athletes in various sporting events, and various political figures. The majority of photographs in the collection are from approximately the 1950s to 1960s and some are signed by entertainers. The collection also includes digital reproductions of approximately half of the images found in the collection.

The Leon Rockwell Photograph Collection (approximately 1850-1979) contains black-and-white photographic prints, negatives, and slides, as well as postcards and tintypes. The images portray the lives of the Rockwell family in southern Nevada, their travels throughout New York and the western United States, and their immediate and extended family members. Also included are images of the volunteer and early firefighters of Las Vegas, Nevada, the Rockwell's family cabin at Mount Charleston, Nevada, and the Rockwell family home in Las Vegas. Portions of the images are from the Rockwell family travels across Nevada, Utah, New Mexico, Arizona, and California and depict historic locations such as Cove Fort, Utah; Rhyolite, Nevada; and Pueblo Grande de Nevada.

The Desert Inn "Black Book" Photograph Collection (1955-1969) consists of 36 black-and-white photographs of individuals arrestest for gambling-related crimes in Reno, Sparks, and Las Vegas, Nevada and Oakland, California. The photographs contain information on the verso with name, date of birth, crime(s) committeed, and known aliases and associates and where gathered by Desert Inn security. These types of photographs were widely circulated amongst casinos, particularly after the formation of the Gaming Control Board in 1955 and the Gaming Control Act in 1959. Crimes listed include slot spooner, slot slugger, dice switcher, and hand mucker.

The Bill Hughes Photographs (approximately 1980-2012) contains negatives, slides, prints, proofs, and born digital images created by local photographer and photojournalist Bill Hughes for publications including Las Vegas CityLife, Las Vegas Business Press, Las Vegas Weekly, as well as commercial clients. A portion of prints in the collection consist of modeling photographs Hughes took as part of his business. The digital images represent a variety of clients, and feature local bands, DJs, and performers in nightclubs and bars on the Strip and downtown Las Vegas. Also included in digital files are portraits, artistic photographs and self-portraits, and material used for Las Vegas Weekly, CityLife, and Business Press.

The Eileen Lancaster Family Photographs contains studio portraits and group photographs taken between approximately 1813 to 1900 of various members of Eileen Lancaster's family. Several of the photographs include notes written on the back by Lancaster listing the name of the family member and the place the photograph was taken. Several of the studio portraits indicate that they were shot at photograph studios in Bradford, England; Hamburg, Germany; Iowa; and Kentucky.

UNLV University Libraries Photographs of the Response to the 1 October Shooting in Las Vegas, Nevada (2017-2019) are comprised of digital images captured to document the aftermath of the mass shooting at the Route 91 Harvest Festival in Las Vegas, Nevada. Following the October 1, 2017 killing of 58 people at the Route 91 Harvest Music Festival on the Las Vegas Strip, the Las Vegas community responded in a variety of ways. This collection of photographs document the impromptu memorial created at the "Welcome to Las Vegas" sign, the funeral of Officer Charleston Hartfield, and different ways the community and organizations have remembered the tragedy since 2017. The collection also documents the Las Vegas Community Healing Garden at 1015 S. Casino Center Boulevard, envisioned by activists and built by volunteers, to honor the victims and give family members and the community a place to gather to remember.

The Clyde F. Merrick Photographic Slides (approximately 1971-1979) contain color photographic slides taken by Clyde F. Merrick, longtime resident of Las Vegas, Nevada. The majority of slides in this collection depict signs for different businesses around Las Vegas including the Las Vegas Strip and the Westside. Some of the businesses documented in this collection includes Fong's Garden, Leon's Shear Magic Beauty Salon, Lucas and Son's Antiques, Dick's Tricky Trikes, Mohan's Custom Tailors, the Twenty Grand Club, Owens TV Repair, and Caesars Palace. The collection also documents a variety of different types of businesses around Las Vegas including bars and nightclubs, beauty salons, car washes, gas stations, and restaurants. Merrick was also a car racing hobbyist and a number of slides in this collection depict what is presumed to be the Las Vegas Speedrome racetrack (later known the Las Vegas Motor Speedway). This collection also includes photographs of locations outside of Las Vegas and Southern Nevada.