The University of Nevada, Las Vegas (UNLV) Office of the President Records is comprised of documents used in daily matters of the Office of the President from approximately 1950 to 2007. The records in the collection document the expansion of the UNLV campus, and the academic and athletics programs offered by the university.

The Yucca Mountain Environmental Safety Collection (1970-2011) consists of reports and impact studies collected by Clark County's Nuclear Waste Division library for documenting Yucca Mountain's potential health and safety risks to Southern Nevada. The reports contain documents pertaining to potential environmental, health, financial, and safety risks from the Yucca Mountain Nuclear Waste Repository, which is located in Nye County, Nevada. The collection contains scientific and social studies in support of and opposition to the site. The bulk of the collection includes licensing reports, site selection studies, and impact studies from transporting, storing, and handling radioactive waste and spent nuclear fuel.

The Howard Hughes Professional and Aeronautical Photographs contain black-and-white photographs of businessman and entrepreneur Howard Hughes and his companies from 1916 to 1997. The photographs primarily depict Hughes alongside his aircraft, including the XF-11 prototype reconnaissance plane and the HK-1 Hercules, better known as the "Spruce Goose" or "Flying Boat." The photographs also cover the companies owned by Hughes, including Hughes Tool Company, Hughes Aircraft Company, Hughes Electronics Corporation, and RKO Pictures.

The Thomas Hickey Political Papers (1964-1996) contain the professional files of Hickey’s career as a Nevada State Assemblyman and Senator. Materials include constituent correspondence, voting records, memoranda, newspaper clippings, bills, and research documentation on topics such as the Yucca Mountain Nuclear Waste Repository, the Equal Rights Amendment (ERA), education, health, prisons, finance, and Nevada infrastructure. The collection highlights Hickey’s role on committees including finance, transportation, government affairs, and ways and means.

The Martha C. Knack and Omer C. Stewart Research Papers on the Pyramid Lake Paiute Tribe contains materials collected by Stewart and Knack as research for their 1984 book, As Long as the River Shall Run: An Ethnohistory of Pyramid Lake Indian Reservation. The collection focuses on the Pyramid Lake Paiute Reservation in Northeastern Nevada from 1845 to 1975 and include letters, journal articles, legal documents, government documents, treatises, and records. All materials are photocopies of documents that date between approximately 1845 to 1980.