The collection includes materials from the Nevada Test Site (1955-1967) including newsletters published by the Reynolds Electrical & Engineering Co., Inc. and photographs of Southern Nevada flora, fauna, and archaeology. It also includes photographs of test explosions at the Nevada Test Site, as well as photographs documenting a visit from North Atlantic Treaty Organization (NATO) officials and a visit from John F. Kennedy to the Nevada Test Site. The collection also contains an oversized poster of an atomic explosion and one of a nuclear rocket development station.

The Thomas P. O'Farrell Papers (1900-1999) are comprised of scientific reports collected by Thomas O’Farrell over the course of his career studying wildlife ecology, particularly its connection to nuclear radiation. Materials include original, reprinted, and photocopied editions of scientific reports on animal and plant life around the world, focusing primarily on the Mojave and Great Basin Deserts, Alaska, Washington, and the Pacific Ocean. Reports come from institutions including the Desert Research Institute (DRI), Oak Ridge National Laboratory (ORNL), the Environmental Protection Agency (EPA), the Energy Research and Development Administration (ERDA), and the United States Department of Energy (DOE), as well as affiliated universities.

Oral history interview with Diane C. Kneeland conducted by Claytee D. White on May 19, 2010 for the Boyer Early Las Vegas Oral History Project. In this interview, Kneeland discusses the history of Las Vegas, Nevada and how the city has developed. Kneeland discusses her husband, William Coulthard, a former state assemblyman; the casinos she would visit on the Las Vegas Strip; and volunteering in the Junior League. Lastly, she describes life in Las Vegas during the 1950s, the entertainment available in Las Vegas, and nuclear weapons tests.

Oral history interview with Polly F. Lilly conducted by Connie L. Patterson on March 26, 1976 for the Ralph Roske Oral History Project. In this interview, Lilly discusses a range of topics, from building a Catholic church in early Las Vegas, Nevada, to the nearby nuclear weapons tests. She also describes witnessing a confrontation between Senator Joseph McCarthy and Hank Greenspun on stage at the now demolished War Memorial Building in Las Vegas, Nevada.

Oral history interview with Maurine Swarts conducted by Teresa McGhie on May 01, 1976 for the Ralph Roske Oral History Project on Early Las Vegas. In this interview, Swarts discusses her personal history and Southern Nevada history. Swarts discusses the crash of Carole Lombard's plane, above ground nuclear tests, and her recreational interests. Swarts also describes how Las Vegas, Nevada has changed.