The Las Vegas, Nevada Gay, Lesbian, Bisexual, Transgender, and Queer/Questioning (LGBTQ) Collection documents the social and political activities of Las Vegas, Nevada's LGBTQ community from 1955 to 2020. The collection includes hundreds of newspaper articles about LGBTQ issues, ranging from AIDS to Nevada legislation. The collection also documents the presence of the LGBTQ community in Las Vegas, including material from gay bars, nightclubs, social clubs, advocacy and political organizations, entertainers, and student groups. Previously known as the Las Vegas Gay, Lesbian, Bisexual, and Transgender Collection.

Oral history interview with Dorothy Frassmann conducted by Dennis McBride on September 21, 1997 for the Las Vegas Gay Archives Oral History Project. Frassmann discusses her upbringing from New York, Canada, and Las Vegas, Nevada, notably as a lesbian.

Oral history interview with Richard Ham conducted by Dennis McBride on January 18, 2002 for the Las Vegas Gay, Bisexual and Transgender Archives Oral History Project. In this interview, Ham discusses the assault of Nevada Supreme Court Justice Frank McNamee in 1965. Ham describes being accused by McNamee of being a communist, McNamee's sexuality, and how McNamee was able to succeed politically despite being a gay man. He continues, discussing the history of the trial following McNamee's assault, and also describes other aspects of Nevada's political history during that time. Ham concludes by discussing being gay and some of his sexual experiences with men.

Oral history interview with Maureen Mackey conducted by Dennis McBride on January 10, 1998 for the Las Vegas Gay Archives Oral History Project. Mackey discusses stories about her life and spiritual journey as a lesbian reverend and reveals her experiences of discriminatory treatment of gay people by traditional religion.

Oral history interview with Lavern Cummings and Tony Midnite conducted by Dennis McBride on August 29, 2000 for the Las Vegas Gay Archives Oral History Project. In the interview, Cummings and Midnite discuss their work as female impersonators in Las Vegas, Nevada during the late 1960s and 1970s. They also talk about other impersonators and performance venues in Las Vegas and around the United States. They explain the distinctions between transgender and straight performers, and the perceptions of transgender and straight audience members. Other subjects Cummings and Midnite cover include their early lives and arrivals to Las Vegas, and the history of sex reassignment surgeries beginning in the 1930s.

The Shar Rednour and Jackie Strano Papers on S.I.R. Productions (1981-2015) contain the personal and professional papers of Rednour and Strano, two lesbian filmmakers, writers, and activists from the 1990s until the 2010s. The collection contains the personal papers of both Rednour and Strano, including correspondence between the pair before they married in 2006. The collection also contains the professional files of Rednour and Strano in their capacity as creators of SIR (Sex, Indulgence, and Rock and Roll) Video in 1998. Materials include financial documents, correspondence, scripts and editing notes, crew information, publicity photographs, and direct order forms for S.I.R. Productions. In addition to records on SIR Video, the collection also contains a number of sex-positive and lesbian, gay, bisexual, transgender, and queer (LGBTQ) publications from the LGBTQ scene in San Francisco, California during the 1990s.

Oral history interviews with Susan and Holly Carratelli conducted by Dennis McBride on June 24 and 26, 1999 for the Las Vegas Gay Archives Oral History Project. In the interviews, Susan and Holly recall first meeting during the planning for the 1994 National Coming Out Day event in Las Vegas, Nevada. They discuss what they value in a relationship, their past relationship experiences, and their involvement with the Gay and Lesbian Community Center and Metropolitan Community Church. Other subjects they cover include their marriage, anecdotes about living together, having children, their daily routine, and conflicting inter-community perceptions between gay men and women in Las Vegas.