The Alice Lake-Rockwell and Earl Rockwell Photographs depict the Las Vegas, Nevada area from approximately 1880 to 1962. The photographs primarily depict the Lake-Rockwell Family in Las Vegas, including Earl Rockwell with a local baseball team, the Las Vegas Volunteer Fire Department, and the Las Vegas Police. Other photographs include the Hoover (Boulder) Dam construction site and views of the completed dam. The photographs also portray family members from the Rockwell Family.

The Robert E. "Spud" Lake Photographs depict "Spud" Lake, his family, and Las Vegas, Nevada from 1905 to 1947. The photographs include the Las Vegas town site auction, Stewart (Kiel) Ranch, Clark County Courthouse, Eglington Ranch, Helldorado Parade, and Colorado River and the Hoover (Boulder) Dam. The photographs also depict a Las Vegas Chamber of Commerce luncheon honoring Las Vegas pioneers, the Gold Bar Club tent in Pahrump, Nevada, and Fremont Street in Las Vegas.

The Union Pacific Railroad Photographs depict the Union Pacific Railroad Company's tracks, depots, locomotives, and stations in Southern Nevada and Southern California from 1904 to 1973. The photographs primarily depict Union Pacific officials in Las Vegas, Nevada, construction of Boulder City, Nevada and the Hoover (Boulder) Dam, hotels and casinos in Las Vegas, and the aftermath of flooding in 1938 that damaged Union Pacific tracks.

The George Kelly Ryan Photograph Collection (1929) depicts waterways in Southern Nevada and Northern Arizona. The collection consists of eight photographic prints and two photographic negatives depicting Saint Thomas, Black Canyon, Boulder Canyon, and the Colorado River.

The Wengert Family Photographs (1890-1966) depict the lives of the Wengert family. In addition are materials focusing on day-to-day activities such as holiday celebrations, family milestones, and some Southern Nevada Power Company employees. Although there are chronological gaps in the materials, particularly in the early years of Cyril and Lottie’s lives, the images provide historical documentation of this Las Vegas family.

The Clarence L. Cleveland Photographs depict Las Vegas, Nevada and other locations in Southern Nevada from 1932 to 1952. The photographs primarily depict locations on Fremont Street in Las Vegas, including the Pioneer Club, Frontier Club, Sal Sagev Hotel, Overland Hotel, Golden Nugget, and the Smith and Chandler "Indian Traders" store. The photographs also depict the Nevada desert, Lake Mead, Boulder City, Nevada, and the Helldorado Parade in Las Vegas.

The Las Vegas Review-Journal Photograph Collection depicts several events in Las Vegas, Nevada from 1935 to 1983 that were documented by Nevada’s largest newspaper, the Las Vegas Review-Journal. The photographs depict the fire at the Las Vegas School in 1935, the fire at the MGM Grand Hotel and Casino in 1980, an exhibition at the Lost City Museum in 1973, a memorial event honoring the first permanent school in Las Vegas in 1980, and an exhibition at the Nevada State Museum and Historical Society in 1983. The collection also contains photographs of some denizens of Las Vegas, including people at the Hughes Bar in Las Vegas, the last Union Pacific passenger train in Las Vegas, and schoolchildren at the Las Vegas School.