The Biographical series (1970-2007) is comprised of materials that focus on Florence McClure's personal life and provide a broad portrait of her life and work. It includes biographical information in the form of newspaper and magazine articles, interviews, resumes, family documents, and genealogical research. Other important personal documents include awards and honors and general correspondence.

The Political Advocacy series (1969-1998) provides documentation of Florence McClure’s work as a political advocate for women’s issues in Las Vegas, Nevada as well as at the state and national level. Included is her testimony before the U.S. Senate and summaries of her activities in the Nevada State Legislature regarding women’s issues.

The Women's Organzations series (1969-2003) contains documents such as meeting minutes, fliers, notes, brochures, bylaws, event information, and general information that relate to Florence McClure's extensive involvement with women's groups that focused on political, health and social betterment efforts in Nevada. McClure often took a leadership or executive role in these organizations including the Soroptimists International of Greater Las Vegas and the American Association of University Women. McClure was also an active lobbyist for women's rights concerning sexual, domestic, and physical abuse. There are several folders that reflect this including: Community Action Against Rape; a copy of her scrapbook on the founding of CAAR; Community Coalition for Victim's Rights; Families of Murder Victims; Jean Nidetch Women's Center; National Association for Victim's Assistance; Nevada Network Against Domestic Violence; and Safenest.

The Womens Conferences series (1991-2000) contains information on various women's conferences that Florence McClure attended; the folders are organized alphabetically by conference name. Documents include preparatory materials, conference materials, name tags, food and lodging information, event lists, papers presented, and personal notes. There are a number of folders documenting her work at the Fourth World Conference on Women’s Issues hosted by the UN in Beijing, China in September 1995.