The locations in Southern Nevada and the Southwestern United States photographs depict people in Southern Nevada and the Southwestern United States from approximately 1900 to 1975. The photographs include politicians and engineers investigating the Colorado River for the future sight of the Hoover (Boulder) Dam in Black Canyon; Hoover Dam workers and construction; the towns of Goodsprings, Beatty, and Indian Springs in Nevada; the Grand Canyon in Arizona; and Mount Charleston in Nevada. The items described include black-and-white photographic prints, postcards, and negatives; items listed are photographic prints unless otherwise specified.

The people associated with Howard Hughes series dates from 1947-1976 and is composed entirely of reference files of newspaper clippings that document Hughes employees, business associates, competitors, and relatives, as well as politicians and government officials that were of interest to Hughes.

Wilbur Clark's Las Vegas, Nevada business photographs depict Wilbur Clark's businesses in Las Vegas, including the Desert Inn and meetings with other prominent Nevada figures, from 1943 to 1975. The photographs include the celebration of the Desert Inn's first anniversary and Wilbur Clark's 48th birthday party held at the Desert Inn. The photographs also depict Clark meeting with numerous individuals, including politicians such as President Harry Truman, Tennessee Governor Frank Clement, Speaker of the House of Representatives Sam Rayburn, and former First Lady Eleanor Roosevelt; entertainers such as Liberace and Elvis Presley; and Nevada governors Charles Russell and Vail Pittman. The photographs also document the CBS television show hosted at Wilbur and Toni Clark's house. The items described include photographic prints and negatives; items listed are photographic prints unless otherwise specified.

The digital images series (approximately 2000-2011) represent a section of Bill Hughes' work as a photographer and photojournalist. A number of images include bands, DJs, dancers, and performers in various nightclubs and bars in downtown Las Vegas and the Strip, taken for Las Vegas Weekly, including "Acoustic Strip," a weekly performance venue. It also contains a number of portraits taken for Hughes' work at various publications including CityLife and Business Press. Other subjects include politicians and political events; the University of Las Vegas, Nevada; architecture; scenic views of Las Vegas; and self-portraits.