The Howard Hughes Public Relations Reference Files (1931-1997) were compiled by Richard "Dick" Hannah, vice-president of the Los Angeles public relations firm Carl Byoir & Associates, which was hired to direct public relations for Hughes’ companies. The collection is primarily composed of newspaper clippings organized into reference files. A significant number of the files contain articles about Howard Hughes’ personal life, the operations of his companies, and legal and political disputes involving Hughes and his companies. The files also document a range of other subjects related to his business ventures, including aviation, aerospace, defense industries, motion picture studios, film stars, communism in Hollywood, and the House on Un-American Activities Committee (HUAC). Later in life Hughes became obsessed with how he was being portrayed in the media. In addition to collecting magazine articles, newspaper clippings, transcripts, screenplays, and books that referenced him. He also collected newspaper clippings about the activities of print media outlets, columnists, radio-television stations, current and former employees, and competitors. The collection also contains newspaper clippings about Watergate, organized crime, gambling, and Las Vegas and contains press releases, correspondence and records generated by Carl Byoir & Associates as well as Rosemont Enterprise, Inc.

Oral history interview with John Cahlan conducted by Lester Wisbrod on February 18, 1975 for the Ralph Roske Oral History Project on Early Las Vegas. Cahlan discusses his experiences in journalism, including his work as an editor for the Review Journal. He provides details on some of the major events covered by the newspaper and his work in establishing Nellis Air Force Base. Cahlan also describes some of the social changes over time, including the growth of air travel for tourism and gambling.

The Human Radiation Experiments Records (1949-1995) contain reports from the National Environmental Policy Act (NEPA), the Advisory Committee on Human Radiation Experiments (ACHRE), and the U. S. Department of Energy (DOE). Also included are newspaper clippings, a court case brought by the National Association of Radiation Survivors (NARS), and cancer research papers. With the goal of building an atomic bomb using plutonium extracted from uranium, the material also examines the outcomes of radiation exposure done on humans during the late 1940s and early 1950s at the Oak Ridge Nuclear Facility in Tennessee.