The Las Vegas, Nevada Gay, Lesbian, Bisexual, Transgender, and Queer/Questioning (LGBTQ) Collection documents the social and political activities of Las Vegas, Nevada's LGBTQ community from 1955 to 2020. The collection includes hundreds of newspaper articles about LGBTQ issues, ranging from AIDS to Nevada legislation. The collection also documents the presence of the LGBTQ community in Las Vegas, including material from gay bars, nightclubs, social clubs, advocacy and political organizations, entertainers, and student groups. Previously known as the Las Vegas Gay, Lesbian, Bisexual, and Transgender Collection.

The Daly v Daly Collection documents materials produced for and as a result of the lawsuits between Suzanne Daly (formerly Tim Daly), a male-to-female transgender woman, and Nancy Toews Daly from 1980 to 2003. The collection primarily focuses on the motions filed with the Nevada District Courts and Nevada Supreme Court and transcripts of the divorce, the battle for parental rights, and an allegation of civil rights violations.

Oral history interviews with David Parks conducted by Dennis McBride on February 16 and 21, 2000 for the Las Vegas Gay, Lesbian, Bisexual and Transgender Archives Oral History Project. In the interviews, Parks talks about his early life in Boston, Massachusetts, his education, and his service with the United States Air Force, where he was stationed at Nellis Air Force Base in Las Vegas, Nevada in 1967. Parks then recalls understanding his sexuality during his military service and policies regarding gay military personnel. He remembers coming out as gay in 1972, when he attended the University of Nevada, Las Vegas and worked for the City of Las Vegas as a computer operator. He then talks about getting involved with politics, his involvement with gay support organizations including Aid for AIDS of Nevada, and his experiences running as the first openly gay Nevada State Assemblyman in 1996. Lastly, Parks discusses same sex rights legislation that was brought forward during his time in office.

The Tamara Pickett Papers (1977-1998) are comprised of materials related to the experiences of transgendered individuals in America. The collection includes transgender publications, scientific articles about sex reassignment surgery, and informational material provided to Pickett from various doctors as she planned her own sexual reassignment surgery.

Oral history interview with Sarah Serna conducted by Dennis McBride on December 04, 1998 for the Las Vegas Gay, Lesbian, Bisexual and Transgender Archives Oral History Project. Serna opens her interview by discussing her move to Las Vegas, Nevada in 1993, and her first assignment as a Methodist minister to a small congregation in North Las Vegas. Serna then explains how she became involved in LGBT social justice issues after witnessing expressions of homophobia and prejudice within her church. She discusses her involvement with the Las Vegas LGBT community and the development of a pastoral care outreach program, the development of the World AIDS Day prayer vigil, and the foundation of the Community Counseling Center, later renamed Lighthouse Ministry. Serna then talks about her decision to transition from the Methodist Church to the Episcopalian Church and becoming the first Episcopalian priest in Las Vegas to bless same-sex marriages. She also discusses the development of a transitional housing program, changes in the LGBT community in Las Vegas, and many individuals involved in LGBT social justice programs in Las Vegas.

The Michael Loewy Papers (1985-1991) contain bylaws, correspondence, conference programs, suggestions and evaluation forms, agendas, and minutes for the Desert Mountain States Lesbian and Gay Conference. Also included are correspondence from the Lesbian and Gay Academic Union (LGAU) at the University of Nevada, Las Vegas, fliers, and an Empower Each Other directory.