The Florence McClure Papers (1969-2007) are comprised of writings, correspondence, newspaper clippings, handwritten notes, and assorted publications that focus on McClure's work with women's organizations, her efforts on behalf of the Southern Nevada Women's Correctional Facility, and her political advocacy work. It also contains a large number of reference clippings McClure collected on women's issues from local, national, and international publications.

The Robert B. Griffith Photograph Collection (approximately 1950-1970) contains black-and-white and color photographic prints, negatives, and slides of Las Vegas, Nevada including Fremont Street, Helldorado parades, and hotel and casino properties along the Strip including the Sahara Hotel and Casino, the Flamingo Las Vegas, the El Rancho, the Thunderbird Hotel and Casino, and the Hotel Last Frontier. Also included are photographs of Lake Mead Recreation Area and tunnel drilling within and near the Las Vegas Valley, Nevada. Other Nevada locations outside of Las Vegas include Reno, Virginia City, and Crystal Bay, Nevada.

The George Laurence Ullom Photograph Collection (1915-1974) contains photographic prints and negatives created by Las Vegas, Nevada photographer George Laurence "Larry" Ullom. Larry owned and operated Ullom’s Desert Art Studio, which was located in Las Vegas, Nevada. The bulk of the collection consists of Ullom's wedding chapel photography. The collection also includes his photography work for the Bureau of Reclamation, the Agricultural Extension Service, and the Associated Press, Atlantic News, and Acme news bureaus.

The Thomas Hickey Political Papers (1964-1996) contain the professional files of Hickey’s career as a Nevada State Assemblyman and Senator. Materials include constituent correspondence, voting records, memoranda, newspaper clippings, bills, and research documentation on topics such as the Yucca Mountain Nuclear Waste Repository, the Equal Rights Amendment (ERA), education, health, prisons, finance, and Nevada infrastructure. The collection highlights Hickey’s role on committees including finance, transportation, government affairs, and ways and means.

The Howard Hughes Professional and Aeronautical Photographs contain black-and-white photographs of businessman and entrepreneur Howard Hughes and his companies from 1916 to 1997. The photographs primarily depict Hughes alongside his aircraft, including the XF-11 prototype reconnaissance plane and the HK-1 Hercules, better known as the "Spruce Goose" or "Flying Boat." The photographs also cover the companies owned by Hughes, including Hughes Tool Company, Hughes Aircraft Company, Hughes Electronics Corporation, and RKO Pictures.