The Amy Ayoub Papers (1906-2022) document the life and career of Amy Ayoub, a long-time resident of Las Vegas, Nevada. The collection consists of correspondence, photographs, newspaper clippings, research, and other material that document the numerous facets of Ayoub's life. The collection covers many areas: Ayoub's early childhood; her family, including father Bobby Ayoub and stepfather Raymond Sutton; her financial consulting career and political work; her experience working as a prostitute in Nevada and subsequent documentary about being sex trafficked and working in brothels; time spent as the first female Nevada Athletic Commissioner; and more. Digital files include audio and video files of Mike Tyson's 2002 licensure hearing, and video of Ayoub's testimony before the Nevada State Assembly Judiciary Committee for Assembly Bill 67 in 2013. There are also digitized photographs that Ayoub used for the documentary The Zen Speaker: Breaking the Silence.

The Robert Lang Professional Papers (1976-2020) mainly contain urban planning research and reports from former University of Nevada, Las Vegas (UNLV) professor and public policy expert Robert Lang. Materials represent different public policy related projects and issues Lang worked on when he was employed with the Fannie Mae Foundation in Washington, D.C., and Brookings Mountain West and the Lincy Institute at UNLV. Materials also include Lang's teaching files which include course syllabi, class presentation slides, and course readers. Research, notes, and drafts of Lang's books including Boomburbs: The Rise of America's Accidental Cities, Edgeless Cities: Exploring the Elusive Metropolis, and Blue Metros, Red States: The Shifting Urban-Rural Divide in America's Swing States are also represented in the collection. The collection also includes documentation for invited conferences and events documenting different conferences and events, copies of Black's Guide for commercial real estate in the United States.

The Howard Hughes Professional and Aeronautical Photographs contain black-and-white photographs of businessman and entrepreneur Howard Hughes and his companies from 1916 to 1997. The photographs primarily depict Hughes alongside his aircraft, including the XF-11 prototype reconnaissance plane and the HK-1 Hercules, better known as the "Spruce Goose" or "Flying Boat." The photographs also cover the companies owned by Hughes, including Hughes Tool Company, Hughes Aircraft Company, Hughes Electronics Corporation, and RKO Pictures.

The Robert Woodruff Photograph Collection (1900s-1970s) consists of ninety-seven black-and-white photographs of locations and events in Clark County, Nevada. Locations include Las Vegas, Henderson, and Searchlight, Nevada, as well as the Hoover Dam. The majority of the images were taken between 1934 and 1962.

The University of Nevada, Las Vegas School of Nursing Records (1950-2019) contain records documenting the history of the UNLV School of Nursing. The materials include records from the nursing school's Alumni Association, including financial reports, bylaws, correspondence, and membership information; recruitment materials from the School of Nursing, including brochures, photographs, and program requirements; history of the School of Nursing, including photographs, newspaper clippings, a short summary of the program, and a short documentary film comprised of digital video files; and accreditation information, including newspaper articles, accreditation reports, and evaluations of the program from the Nevada State Board. The materials also include nursing student uniforms, caps, and nursing capes from the 1950s and 1960s.

The University of Nevada, Las Vegas Solar Decathlon Records (2013-2021) are comprised of records documenting the University of Nevada, Las Vegas's participation in the U.S. Department of Energy (DOE) Solar Decathlon collegiate competition. The collection includes records created by the 2013, 2017, and 2020 UNLV teams (Team Las Vegas) in designing and building their respective competition entries: DesertSol, Sinatra Living, and Mojave Bloom. Records include competition application files, working project files, As-Built submittal packets, and promotional and marketing files for the competition. The majority of records in this collection represent the 2017 competition. Archived websites and social media accounts associated with Team Las Vegas and the Solar Decathlon competition are also included in the collection. The records document Team Las Vegas's efforts in designing and building energy efficient homes for the Solar Decathlon competition.

The Thomas Hickey Political Papers (1964-1996) contain the professional files of Hickey’s career as a Nevada State Assemblyman and Senator. Materials include constituent correspondence, voting records, memoranda, newspaper clippings, bills, and research documentation on topics such as the Yucca Mountain Nuclear Waste Repository, the Equal Rights Amendment (ERA), education, health, prisons, finance, and Nevada infrastructure. The collection highlights Hickey’s role on committees including finance, transportation, government affairs, and ways and means.