The Sands Hotel Photograph Collection depicts entertainers, celebrities, events, amenities, and staff at the Sands Hotel in Las Vegas, Nevada from approximately 1952 to 1980. The photographs primarily depict entertainers like Frank Sinatra, Dean Martin, and the Copa Girls performing in the Copa Room, the showroom of the Sands Hotel. The photographs also depict patrons gambling, events held in the Sands Hotel's ballrooms, banquets, the pool, rooms in the hotel, as well as Jack Entratter, the hotel'’s director of entertainment.

The Dorothy Dorothy Photograph Collection (approximately 1910-1985) consists of black-and-white photographic prints and negatives as well as colored transparencies of Dorothy Dorothy. Included are photographs of campaigns, meetings, and banquets with various local and federal politicians. Also included are photographs of her husband, Dale Dorothy, and their ranch in Pahrump, Nevada.

The Nevada Political Buttons Collection contains campaign buttons from 1972 to 2000. The collection includes buttons for political candidates at the federal, state, and local levels, including Bill Clinton and Al Gore for President of the United States, Harry Reid for United States Senate from Nevada, Bob Miller for governor of Nevada, and various candidates for Nevada's state legislature and other elected positions. The collection also contains buttons from some of Nevada's local political organizations, including Las Vegas, Nevada's branch of the Culinary Union, Nevada Fair Pay Coalition, and No Nuclear in Nevada.

The Matt Gregory Photograph Collection contains color and black-and-white photographic prints, negatives, and slides of musical and dance shows he produced in Nevada and international locations between 1959 and 1985.

The Claudine Williams Photograph Collection (approximately 2007-2009) consists of nine optical disks containing ninety-eight digital surrogate images dating between 1940 and 2000. The images primarily portray Claudine Williams in publicity images for various hotel and casinos Williams and her husband owned alongside prominent individuals, including Dean Martin, Hillary and Bill Clinton, and Robert Reich. Other images depict Williams in her youth and with her family members. Additional materials include images of Williams’ business cards, articles in various Las Vegas and Nevada magazines and newspapers on Williams, and images of properties Williams operated.

The Leon Rockwell Photograph Collection (approximately 1850-1979) contains black-and-white photographic prints, negatives, and slides, as well as postcards and tintypes. The images portray the lives of the Rockwell family in southern Nevada, their travels throughout New York and the western United States, and their immediate and extended family members. Also included are images of the volunteer and early firefighters of Las Vegas, Nevada, the Rockwell's family cabin at Mount Charleston, Nevada, and the Rockwell family home in Las Vegas. Portions of the images are from the Rockwell family travels across Nevada, Utah, New Mexico, Arizona, and California and depict historic locations such as Cove Fort, Utah; Rhyolite, Nevada; and Pueblo Grande de Nevada.

The Robert Woodruff Photograph Collection (1900s-1970s) consists of ninety-seven black-and-white photographs of locations and events in Clark County, Nevada. Locations include Las Vegas, Henderson, and Searchlight, Nevada, as well as the Hoover Dam. The majority of the images were taken between 1934 and 1962.