The Carolyn Merriam Collection on the Sands Hotel (1972-1998) consists primarily of Sands Hotel merchandise and ephemera, including mugs, glassware, playing cards, dice, an ashtray, and a tote bag. The collection also contains several framed photograph reproductions depicting Las Vegas, Nevada in the 1950s and 1960s. The Sands Hotel operated in Las Vegas, Nevada from 1952 to 1996.

The collection is comprised of architectural drawings (1952-1997) completed by American architect, Ethan Jennings Jr. and/or his architectural firm, Ethan Jennings Jr., AIA, CSI and includes Jenning's work from the firm of John Badgley, AIA, where Ethan Jennings Jr. worked in Southern California during the 1950s, as well as work Jenning's completed with Americo Inc., and Tolosa Group. The collection contains 217 sets of drawings, 6 boxes of project records, and 8 flat files of oversized material from over 200 different projects primarily located in California with some projects located in the Las Vegas area. The materials feature hand-drawn architectural drawings, ranging from preliminary sketches to construction documents. The drawings also contain work from consultants, engineers, and other architects who collaborated on the development of the various projects. The drawings include: commercial, industrial, professional, civic, residential, and religious buildings of varying scales, such as libraries, apartments, warehouses, office developments, schools, military buildings, churches, and custom single-family homes located throughout California and Las Vegas. The drawings also include a number of additions, remodels, and renovations. The collection also contains project records like structural calculations and drawings, project manuals and specifications, bid documents, and professional correspondence.

The Kenneth Giles Professional Papers (1964-2001) contain documents and visual material related to Giles's time as an Environmental Radiation Monitor for the Environmental Protection Agency (EPA) at the Nevada Test Site (NTS). Photographic slides, film, and digital images depict the general flora and fauna throughout the area surrounding the NTS. Visual materials also document specific mule deer and steer surveillance and testing at the EPA Farm located within the NTS. The collection also contains environmental reports written or collected by Giles, government documents, pamphlets, and newspaper clippings related to environmental monitoring and Giles's work at NTS. A small portion of the collection documents his brief role providing monitoring support at Three Mile Island in Pennsylvania in 1979. Note: Some images may be of a graphic or disturbing nature and may not be suitable for some users. Photographs may contain scenes of animal testing or other objectionable imagery.

The Cliff Trenier Papers (approximately 1950-1999) document the life and career of Clifton "Cliff" Trenier, who performed with various siblings across the United States beginning in the 1940s. The collection contains photographs of Cliff with his twin brother Claude performing, documents and newspaper clippings relating to the musical group's tours and their numerous performances in Las Vegas, Nevada including at the Moulin Rouge. Also included in the collection are photographs of Cliff's wife, Bedez, and correspondence between the couple up until Cliff's illness and death in 1983.

The Southern Nevada Gem and Mineral Society Records (1950-2012) contain the records of the Clark County Gem Collectors, Las Vegas Gem Collectors, and the current Southern Nevada Gem and Mineral Society. The collection contains articles of incorporation, by-laws, membership directories, meeting minutes, correspondence, financial records, show paperwork, and award certificates. Also included are photographs of the organizations since the 1970s and digital scans of Gem Times and The Polished Slab newsletters.

The Wilson Family Papers (1875-1918) document the personal and professional lives of James B. Wilson Sr., James B. Wilson Jr., and George Twison "Tweed" Wilson, early pioneers in Southern Nevada. The collection is comprised of personal correspondence, invoices and advertisements from the Wilson family business, the Sandstone Ranch, and photographs of the extended Wilson family.

The Archie and Zora Grant Papers document the lives of Archie and Zora Grant from 1918 to 1973. Materials include scrapbooks, clippings, correspondence, records, certificates, and awards pertaining to Archie’s career in the Nevada Legislature, the State Board of Education, Las Vegas Housing Authority, and Las Vegas Chamber of Commerce.