The Sands Hotel Photograph Collection depicts entertainers, celebrities, events, amenities, and staff at the Sands Hotel in Las Vegas, Nevada from approximately 1952 to 1980. The photographs primarily depict entertainers like Frank Sinatra, Dean Martin, and the Copa Girls performing in the Copa Room, the showroom of the Sands Hotel. The photographs also depict patrons gambling, events held in the Sands Hotel's ballrooms, banquets, the pool, rooms in the hotel, as well as Jack Entratter, the hotel'’s director of entertainment.

The Tonopah-Goldfield Mining Photograph Collection depicts mining activities in the mining towns of Tonopah and Goldfield in Esmeralda County, Nevada from approximately 1901 to 1920. The photographs primarily depict mines, miners, mills, construction, ore, and workers transporting ore. The photographs also depict events and people in Tonopah and Goldfield, including parades, celebrations, banquets, children, Native Americans, and prominent buildings.

The Howard Cannon Photograph Collection (1950-1983) contains photographic prints, negatives, and one slide featuring Senator Howard Cannon at various political and publicity events with military personnel, political colleagues, and constituents primarily in the state of Nevada. Other photographs feature Cannon at political and publicity events outside of Nevada including California, New York, Florida, Oregon, and Washington, D.C.

The Henry C. Wieking Photograph Collection contains black-and-white photographic prints and negatives, as well as postcards of Las Vegas, Nevada between approximately 1920 and 1940. These images primarily depict Wieking and his family in front of the Las Vegas Mormon Fort and Hoover Dam (Boulder Dam). Other photographs include Six Companies and United States Bureau of Reclamation vehicles, Mount Charleston, the Colorado River, Black Canyon, and desert scenes. The remaining images depict Barstow and Death Valley, California; and a Grand Canyon bridge in Arizona.

The Tomiyasu Family Photograph Collection (approximately 1908 to 1991) consists of black-and-white photographic prints of the Tomiyasu family and their farming business in southern Nevada.

The Robert Woodruff Photograph Collection (1900s-1970s) consists of ninety-seven black-and-white photographs of locations and events in Clark County, Nevada. Locations include Las Vegas, Henderson, and Searchlight, Nevada, as well as the Hoover Dam. The majority of the images were taken between 1934 and 1962.

The Thomas J. Osborne Photograph Collection (approximately 1890-1930) consists of black-and-white photographic prints, negatives, and slides. Images depict the family of Thomas J. Osborne, his law office, the family home, and views of the town of Pioche, Nevada and surrounding areas. Several images depict local mines and unidentified mine workers.