The collection includes materials from the Nevada Test Site (1955-1967) including newsletters published by the Reynolds Electrical & Engineering Co., Inc. and photographs of Southern Nevada flora, fauna, and archaeology. It also includes photographs of test explosions at the Nevada Test Site, as well as photographs documenting a visit from North Atlantic Treaty Organization (NATO) officials and a visit from John F. Kennedy to the Nevada Test Site. The collection also contains an oversized poster of an atomic explosion and one of a nuclear rocket development station.

The Central Nevada Historical Society Photograph Collection (1880-1982) contains photographs from central Nevada towns, mines, and railroads. The photographs primarily depict events and mining operations from the early-twentieth century in or around Tonopah, Goldfield, Belmont, Manhattan, Montezuma, and Big Smoky Valley. The photographs also depict the Tonopah & Goldfield Railroad, the Las Vegas & Tonopah Railroad, the "Priscilla" nuclear bomb test at the Nevada Test Site, horse-drawn freight carriages, and building construction. Other towns also featured in the collection include Silver Peak, Bullfrog, Rawhide, Ellendale, Columbus, Berlin, Palmetto, Gilbert, Blair, Klondyke, Wahmonie, Diamondfield, Miller's, and Candelaria.