The Bill Willard Photograph Collection depicts Las Vegas, Nevada, hotels and casinos in Las Vegas, the Las Vegas Valley, and Laughlin, Nevada from 1905 to 1919 and from 1940 to 1999. The photographs primarily depict hotels and casinos in Las Vegas, including the Sahara Hotel, Circus Circus Hotel and Casino, MGM Grand Las Vegas Hotel and Casino, Caesars Palace, Flamingo Hotel, and the Aladdin Hotel. The photographs also depict students at Nevada Southern University (predecessor of the University of Nevada, Las Vegas), the city of Las Vegas, industrial plants in Henderson and Apex, Nevada, and events in Laughlin, Nevada.

The James Cashman Sr. Photograph Collection (approximately 1905 to 1975) consists of black-and-white photographic prints, negatives, slides, and albums as well as a glass plate negative. The photographs depict four major subjects: Cashman's family, friends, and associates; Cashman's businesses; the Hoover Dam and Colorado River; and various locations across Nevada.

The Mike Smith Editorial Cartoons (1980-2023) contain editorial cartoons created by Las Vegas, Nevada based cartoonist Mike Smith for the Las Vegas Sun newspaper. Materials include Smith's editorial cartoons on NASCAR and a copy of his 2003 book StockcarToons. The collection also includes Smith's personal sketchbooks and letters from fans.

The Florence McClure Papers (1969-2007) are comprised of writings, correspondence, newspaper clippings, handwritten notes, and assorted publications that focus on McClure's work with women's organizations, her efforts on behalf of the Southern Nevada Women's Correctional Facility, and her political advocacy work. It also contains a large number of reference clippings McClure collected on women's issues from local, national, and international publications.

The Lori Lipman Brown Papers date from 1975 to 2009 and document former Nevada State Senator Lori Lipman Brown's political career. It includes correspondence and materials from Brown's service as a Nevada State Senator from 1992 to 1994, case files from her defamation lawsuit against Nevada State Senator Kathy Augustine, and papers from her work opposing the Nevada Question 2 ballot measure on same-sex marriage in 2000. The collection also contains photocopies of biographical materials and personal and publicity photographs of Brown, as well as material from her time working with local high school and commmunity theatre programs.

The Senator Chic Hecht Political Papers (1943-1988) contain the political papers of United States Senator and Las Vegas, Nevada businessman Chic Hecht. The bulk of the collection contains legislation, notes, correspondence between Hecht and constituents and other members of Congress, and speeches from Senator Hecht's term in the Senate from 1982 to 1988. Also included are files on civil service, the federal budget, education, labor, transportation, land management, foreign policy, public health, and trade.