The Howard Hughes Professional and Aeronautical Photographs contain black-and-white photographs of businessman and entrepreneur Howard Hughes and his companies from 1916 to 1997. The photographs primarily depict Hughes alongside his aircraft, including the XF-11 prototype reconnaissance plane and the HK-1 Hercules, better known as the "Spruce Goose" or "Flying Boat." The photographs also cover the companies owned by Hughes, including Hughes Tool Company, Hughes Aircraft Company, Hughes Electronics Corporation, and RKO Pictures.

The Howard Hughes Public Relations Photograph Collection depicts the activities of businessman Howard Hughes from 1930 to 1950. The photographs primarily depict aircraft flown by Hughes or designed by the Hughes Aircraft Company, including the XF-11 reconnaissance plane, the HK-1 Hercules (or "Spruce Goose"), and the Hughes H-1 Racer. The photographs also depict celebrations following Hughes's circumnavigation flight in New York City, New York and Chicago, Illinois in 1938. Lastly, the photographs include Hughes testifying in front of the Senate Special Committee to Investigate the National Defense Program in 1947.