The Yucca Mountain Environmental Safety Collection (1970-2011) consists of reports and impact studies collected by Clark County's Nuclear Waste Division library for documenting Yucca Mountain's potential health and safety risks to Southern Nevada. The reports contain documents pertaining to potential environmental, health, financial, and safety risks from the Yucca Mountain Nuclear Waste Repository, which is located in Nye County, Nevada. The collection contains scientific and social studies in support of and opposition to the site. The bulk of the collection includes licensing reports, site selection studies, and impact studies from transporting, storing, and handling radioactive waste and spent nuclear fuel.

The collection is comprised of architectural drawings (1952-1997) completed by American architect, Ethan Jennings Jr. and/or his architectural firm, Ethan Jennings Jr., AIA, CSI and includes Jenning's work from the firm of John Badgley, AIA, where Ethan Jennings Jr. worked in Southern California during the 1950s, as well as work Jenning's completed with Americo Inc., and Tolosa Group. The collection contains 217 sets of drawings, 6 boxes of project records, and 8 flat files of oversized material from over 200 different projects primarily located in California with some projects located in the Las Vegas area. The materials feature hand-drawn architectural drawings, ranging from preliminary sketches to construction documents. The drawings also contain work from consultants, engineers, and other architects who collaborated on the development of the various projects. The drawings include: commercial, industrial, professional, civic, residential, and religious buildings of varying scales, such as libraries, apartments, warehouses, office developments, schools, military buildings, churches, and custom single-family homes located throughout California and Las Vegas. The drawings also include a number of additions, remodels, and renovations. The collection also contains project records like structural calculations and drawings, project manuals and specifications, bid documents, and professional correspondence.

The Sister Klaryta Antoszewska Photograph Collection (1977-1991) consists of photographic slides that depict various Nevada, United States, and international nuclear test protests. The collection includes images of Sister Klaryta Antoszewska and Sister Rosemary Lynch, as well as images of the Lenten Desert Experience and numerous protests at the Nevada Test Site. Also included are images of nuclear testing, soldiers, and anti-nuclear testing promotional materials.

The Archie C. Grant Photograph Collection (1914-1968) contains black-and-white photographs of Nevada politician Archie C. Grant. The materials include photographs of Grant with the Las Vegas Housing Authority at groundbreaking ceremonies, the University of Nevada Board of Regents, and with other Nevada politicians. Materials also contain early photographs of the University of Nevada, Las Vegas campus, including the dedication of Maude Frazier Hall.

The Nevada Desert Experience Records (1951-2009) are comprised of files from the anti-nuclear organization, the Nevada Desert Experience (NDE), as well as its predecessor, the Sagebrush Alliance, and those of earlier unincorporated protests at the Nevada Test Site (NTS). Materials include board of directors meeting minutes, financial records, scrapbooks, personnel records, event speeches, correspondence, newspaper clippings, cartoons and other artwork, newsletters, brochures, fliers, research files on nuclear issues and other anti-nuclear organizations, and congressional testimony. The records also contain audiovisual materials, photographic prints and slides, screenplays, manuscripts, and newspapers related to the NDE's media efforts.