The Murphy-Farmer collection contains black-and-white photographic prints (approximately 1930-1959) depicting locations around southern Nevada, including Lake Mead, Hoover Dam, Las Vegas, and Boulder City, Nevada.

The Elmo and Charlotte Ellsworth Photograph Collection (approximately 1940-1959) is comprised of black-and-white photographic prints and negatives. The images depict Charlotte and Elmo Ellsworth. Also included is an image of Elmo Ellsworth on horseback at the Las Vegas, Nevada airport for the arrival of the first United Airlines flight and an image of people at the Last Frontier Village in Las Vegas.

The James H. Down Jr. Photograph Collection (approximately 1915-1940) consists of black-and-white photographic prints and negatives, as well as color photographic slides and postcards. The images depict scenes in and around Las Vegas and Goodsprings, Nevada. Also included are Glenn Davis' photographs of the Hoover Dam (Boulder Dam), Black Canyon, the Colorado River, and Lake Mead. Most of the images portray the construction phases of the Hoover Dam.

The Marie and James B. McMillan Photograph Collection (1900-1994) contains photographs of Marie and James B. McMillan and their families. The collection also includes photographs of their friends and professional associates, including journalist Hank Greenspun, Nevada civil rights pioneer J. David Hoggard, and entertainer Sammy Davis Jr. Marie McMillan is a former Las Vegas, Nevada flight instructor and one of the first women to work at the Nevada Test Site in Nye County, Nevada. James B. McMillan was the first African-American dentist to practice in Nevada, as well as a prominent Nevada civil rights leader.

The Nevada Nurses Association Photograph Collection (approximately 1980-1990) is comprised of seventy-six photographic slides, and six color photographic prints that depict the Nevada Nurses Association conference held at the Sahara Hotel and Casino in Las Vegas, Nevada. The collection also includes black-and-white negatives from the 1986 Legislators' brunch in Las Vegas, Nevada.

The Reverend Donald M. Clark Photograph Collection (approximately 1965-1978) is comprised of black-and-white photographic prints and negatives. The bulk of the images portray Reverend Clark’s work with black communities in Las Vegas, Nevada and the Lake Tahoe area. Additional images depict Reverend Clark with various prominent individuals in the civil rights movement, including boxer Joe Frazier and American gospel singer Mahalia Jackson.

The James Hulse Photograph Collection on Pioche, Nevada contains photographs and postcards from Pioche, Nevada from 1905 to 1951. The photographs primarily depict the town, mining operations, and the Lincoln County Courthouse. The photographs also depict the town during a fire in 1947, the Power & Electric company, several buildings in the town, and Main Street.