The Ferron and Bracken Photograph Collection depicts Southern and Central Nevada and other western states from 1890 to 1961. The photographs primarily depict the development and growth of early Las Vegas, Nevada; mines and mining operations in Southern and Central Nevada; towns and mines in Nevada; and the Hoover (Boulder) Dam and the Colorado River.

The Squires Family Photographs document the Squires Family and the development of the Las Vegas Valley in Nevada from approximately 1860 to 1980, with a bulk of the photographs depicting people and events from 1900 to 1950. The photographs depict the Euro-American settlement and growth of Las Vegas, Nevada; traveling and exploration of Southern Nevada and the Southwestern United States; the Hoover (Boulder) Dam and the Colorado River; clubs and social groups; and the Squires Family, especially prominent newspaper editor and publisher Charles Pember (C. P. or “Pop”) Squires, Delphine “Mom” Anderson Squires, and their children.

The Harry Floyd Alter Photograph Collection (1905-1916) is comprised of black-and-white photographic prints and negatives. The images depict scenes in Las Vegas, Nevada, including the Las Vegas Ranch, the Arizona Club, and baseball teams and fields. Also included are images of Harry Floyd Alter and his friends.

The North Las Vegas Bicentennial Committee Photographs and Drawings of Kiel Ranch document the buildings on Kiel (Kyle) Ranch in 1974. As part of the commemoration of the United States bicentennial, the North Las Vegas City Council elected to restore Kiel Ranch, which was one of the first non-indigenous settlements in the Las Vegas Valley. The materials include black-and-white photographs of Kiel Ranch as it was in 1974 as well as architectural drawings of planned renovations to the main house, the Brown House, the foreman's house, and the ranch hands' house.

The Robert Worts Photographs depict the Corn Creek Ranch in Nevada from 1936 to 1939. Located northwest of Las Vegas, Nevada, Corn Creek Ranch was home to writer George F. Worts in the late 1930s. Materials in the collection include photographs of Worts, buildings on Corn Creek Ranch, and a camp on Mount Charleston.

The Lake-Eglington Family Photograph Collection contains photographs of the Lake-Eglington Family in and around Las Vegas, Nevada from 1900 to 1976. The materials include photographs of early Las Vegas resident Olive Lake-Eglington and her family shortly after they moved to Las Vegas in 1904, as well as her eventual husband Earle Eglington after he moved to Las Vegas in 1911. The materials also include photographs of Native American artifacts, schools in Clark County, Nevada, artesian wells, the Hoover (Boulder) Dam, the Colorado River, Mt. Charleston, the Mormon Fort, the Stewart (Kiel) Ranch, the Las Vegas Ranch, and many early residents of Las Vegas.

The Betty Ham Dokter Photographs depict the Ham Family from 1850 to 1976. The materials include photographs of the family after they moved to Las Vegas, Nevada in 1916 and document the early growth of the city. The materials also include photographs of the Colorado River, the Hoover (Boulder) Dam site before and after its construction, dinner parties, family photographs, and citizens of the Las Vegas area. The materials also include photographs of Alta Mereness Ham, Betty Ham Dokter's mother, on the set of the film Water.