Wilbur Clark's Las Vegas, Nevada business photographs depict Wilbur Clark's businesses in Las Vegas, including the Desert Inn and meetings with other prominent Nevada figures, from 1943 to 1975. The photographs include the celebration of the Desert Inn's first anniversary and Wilbur Clark's 48th birthday party held at the Desert Inn. The photographs also depict Clark meeting with numerous individuals, including politicians such as President Harry Truman, Tennessee Governor Frank Clement, Speaker of the House of Representatives Sam Rayburn, and former First Lady Eleanor Roosevelt; entertainers such as Liberace and Elvis Presley; and Nevada governors Charles Russell and Vail Pittman. The photographs also document the CBS television show hosted at Wilbur and Toni Clark's house. The items described include photographic prints and negatives; items listed are photographic prints unless otherwise specified.

Wilbur Clark's personal photographs depict Wilbur Clark and his family from approximately 1910 to 1960. The photographs include Clark as a child and his hometown of Keyesport, Illinois. The photographs primarily depict Clark and his wife Toni, their friends, and their home in Las Vegas, Nevada.