Materials contain photographs related to RKO Pictures (Radio-Keith-Orpheum) and Howard Hughes's movies from 1928 to 1959. The photographs primarily depict Howard Hughes on the set of the film The Outlaw (1943), which he directed. The photographs also include portraits of RKO actors, including Frank Sinatra, Jane Russell, and Claudette Colbert. Hughes purchased RKO in 1948.

Materials contain photographs of Las Vegas, Nevada from 1960 to 1979. The photographs primarily depict properties owned by Howard Hughes after he moved to Las Vegas in 1966, including the Desert Inn, the Silver Slipper, the Landmark Hotel, the Sands Hotel, and the Frontier Hotel. The photographs also include the Spring Mountain Ranch that Hughes purchased for his wife Jean Peters and aerial views of the Las Vegas Strip.