The Howard Hughes Public Relations Photograph Collection depicts the activities of businessman Howard Hughes from 1930 to 1950. The photographs primarily depict aircraft flown by Hughes or designed by the Hughes Aircraft Company, including the XF-11 reconnaissance plane, the HK-1 Hercules (or "Spruce Goose"), and the Hughes H-1 Racer. The photographs also depict celebrations following Hughes's circumnavigation flight in New York City, New York and Chicago, Illinois in 1938. Lastly, the photographs include Hughes testifying in front of the Senate Special Committee to Investigate the National Defense Program in 1947.

The Pueblo Grande de Nevada Photograph Collection (approximately 1920-1980) contains black-and-white photographic prints, negatives, and slides depicting archaeological sites located in Overton, Moapa, Valley of Fire, Red Rock, Pyramid Lake, Kane Springs, Virgin River, the “Lost City,” and Lake Mead, Nevada. Images display the different stages of digging during the archaeological excavation of Pueblo Grande de Nevada. Also included are images showcasing artifacts uncovered during the excavations, the Saint Thomas, Nevada and the flooding of archaeological sites after the construction of the Hoover (Boulder) Dam.

The Edward G. Halligan Photograph Collection on the Nevada Test Site contains photographs of nuclear detonations at the Nevada Test Site from the 1960s. The photographs primarily depict aboveground nuclear explosions, but they also contain photographs of facilities, machinery, and personnel at the Nevada Test Site.

The Dorothy Ray Photograph Collection on Southern Nevada, approximately 1900-1946, depicts infrastructure in Caliente, Nevada in the early to mid-twentieth century. The collection also contains images of a flash flood that occurred in 1905 in Carp, Nevada and Stine, Nevada that washed away roads and railroad tracks. This collection provides historical documentation about early to mid-century Caliente, Nevada.

The First Methodist Church Photograph Collection (approximately 1909-1912) contains black-and-white photographic prints and corresponding negatives of the Las Vegas train depot, railroad yards, and the First Methodist Church in Las Vegas, Nevada. Also included are portraits of Reverend Edwin A. Palmer and his family.