The Marie and James B. McMillan Photograph Collection (1900-1994) contains photographs of Marie and James B. McMillan and their families. The collection also includes photographs of their friends and professional associates, including journalist Hank Greenspun, Nevada civil rights pioneer J. David Hoggard, and entertainer Sammy Davis Jr. Marie McMillan is a former Las Vegas, Nevada flight instructor and one of the first women to work at the Nevada Test Site in Nye County, Nevada. James B. McMillan was the first African-American dentist to practice in Nevada, as well as a prominent Nevada civil rights leader.

The James H. Down Jr. Photograph Collection (approximately 1915-1940) consists of black-and-white photographic prints and negatives, as well as color photographic slides and postcards. The images depict scenes in and around Las Vegas and Goodsprings, Nevada. Also included are Glenn Davis' photographs of the Hoover Dam (Boulder Dam), Black Canyon, the Colorado River, and Lake Mead. Most of the images portray the construction phases of the Hoover Dam.

The Nevada Nurses Association Photograph Collection (approximately 1980-1990) is comprised of seventy-six photographic slides, and six color photographic prints that depict the Nevada Nurses Association conference held at the Sahara Hotel and Casino in Las Vegas, Nevada. The collection also includes black-and-white negatives from the 1986 Legislators' brunch in Las Vegas, Nevada.

The James Hulse Photograph Collection on Pioche, Nevada contains photographs and postcards from Pioche, Nevada from 1905 to 1951. The photographs primarily depict the town, mining operations, and the Lincoln County Courthouse. The photographs also depict the town during a fire in 1947, the Power & Electric company, several buildings in the town, and Main Street.

The Edward Joseph Deck Photograph Collection (approximately 1870-1920) consists of photographic prints and negatives of Edward Joseph Deck and other miners in Pioche, Nevada and various locations around the townsite. There are also images of ranches, mills, and mill workers both in and outside of the Pioche townsite.

The Marian Honeycutt Photograph Collection (1963-1969) is comprised of snapshots taken of famous Las Vegas landmarks in the 1960s. Among the landmarks depicted are: the Golden Nugget, the Golden Slipper, the Desert Inn Hotel, and the Sahara Hotel. Some of the snapshots were taken from the interior of a vehicle.